On interrogating electron microscopy images to discover proteins in the cell

IF 2.9 2区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

IUCrJ Pub Date : 2025-03-01 DOI:10.1107/S2052252525001861

Jose-Maria Carazo

引用次数: 0

Abstract

Interrogating individual two-dimensional (2D) cryo-EM images for the presence of defined three-dimensional (3D) structures that correspond to previously known (or predicted) macromolecular complexes is very challenging, but offers attractive opportunities for the analysis of large numbers of specimens. The work of Zhang et al.[(2025), IUCrJ, 12, 155–176] represents a significant step forward towards this goal.

查看原文本刊更多论文

利用电子显微镜图像来发现细胞中的蛋白质。

查询单个二维（2D）冷冻电镜图像是否存在与先前已知（或预测）大分子复合物对应的定义三维（3D）结构是非常具有挑战性的，但为大量标本的分析提供了有吸引力的机会。Zhang等人[2025]，IUCrJ, 12, https://doi.org/10.1107/S2052252524011771]]的工作是朝着这一目标迈出的重要一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IUCrJ CHEMISTRY, MULTIDISCIPLINARYCRYSTALLOGRAPH-CRYSTALLOGRAPHY

CiteScore

7.50

自引率

5.10%

发文量

审稿时长

10 weeks

期刊介绍： IUCrJ is a new fully open-access peer-reviewed journal from the International Union of Crystallography (IUCr). The journal will publish high-profile articles on all aspects of the sciences and technologies supported by the IUCr via its commissions, including emerging fields where structural results underpin the science reported in the article. Our aim is to make IUCrJ the natural home for high-quality structural science results. Chemists, biologists, physicists and material scientists will be actively encouraged to report their structural studies in IUCrJ.