High-Performance Data Acquisition for Fourier Transform Mass Spectrometry.

Abstract

High-performance data acquisition and processing (DAQ) systems are characterized by their ability to capture, process, and transmit data with high speed, precision, and efficiency. Among commercial solutions for Fourier transform mass spectrometry (FTMS), the FTMS Boosters developed by Spectroswiss stand out. These systems enhance the capabilities of FTMS platforms, such as Orbitrap and ion cyclotron resonance (ICR) instruments, by improving mass resolution, sensitivity, and data handling. This review highlights the impact of FTMS Boosters across six key applications: mass spectrometry imaging, charge detection mass spectrometry (CDMS) and charge determination analysis (CHARDA), biopharmaceutical analysis, isotope ratio and trace analyses, super-resolution mass spectrometry, and complex mixture analysis. By advancing FTMS capabilities, FTMS Boosters not only elevate performance but also extend the operational lifespan of legacy FTMS systems, offering a sustainable and cost-effective path to improved MS functionality. As FTMS technologies advance with an increasing focus on acquiring and processing big data, FTMS Boosters, and other high-performance DAQ systems are set to become indispensable in addressing the growing demands of data-intensive scientific research and applications.