A Dual-Channel Fluorescent Probe for Detection of Biothiols in Green and Further Differentiation of Cys/Hcy in Near-Infrared Regions

IF 3.2 4区化学 Q2 CHEMISTRY, ANALYTICAL

Luminescence Pub Date : 2025-03-03 DOI:10.1002/bio.70142

Yuyuan Sun, Hui Wang, Xulong He, Fan Liu, Yu Yuan, Xiaodong Jia, Gang Chen, Shuwei Zhang

引用次数: 0

Abstract

Biothiols like cysteine and homocysteine have important physiological activities in organisms. Therefore, the effective monitoring of such substances holds special significance. In this work, a dual-channel fluorescent probe DEHQ-NBD was developed for the detection of biothiols in green and further differentiation of Cys/Hcy in NIR regions. Meanwhile, the probe exhibits good photostability, rapid response, and low cytotoxicity, which has been successfully applied in cell imaging.

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绿色生物硫醇双通道荧光探针检测及近红外区域Cys/Hcy的进一步分化

半胱氨酸和同型半胱氨酸等生物硫醇在生物体中具有重要的生理活性。因此，对此类物质进行有效的监测具有特殊的意义。本研究开发了一种双通道荧光探针DEHQ-NBD，用于检测绿色生物硫醇，并进一步区分近红外区域的Cys/Hcy。同时，该探针具有良好的光稳定性、快速响应和低细胞毒性，已成功应用于细胞成像。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Luminescence 生物-生化与分子生物学

CiteScore

5.10

自引率

13.80%

发文量

248

审稿时长

3.5 months

期刊介绍： Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.