Frontispiz: Konformationsplastizität und Steigerung der Bindungsaffinität durch Linker-Derivatisierung in Makrozyklen

Vanessa Buffa, Carlo Walz, Dr. Christian Meyners, Dr. Min Zheng, Wisely Oki Sugiarto, Maximilian Repity, Hanaa Achaq, Christian Brudy, Moritz Spiske, Matijas Cica, Prof. Dr. Felix Hausch
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引用次数: 0

Abstract

Macrocycles like the ones depicted in the rod-and-ball representation shown in the picture can enable powerful drugs but their exploration has been difficult. The build--pair--couple strategy reported by Felix Hausch et al. in their Research Article (e202418512) allows the rapid assembly of diversely decorated macrocycles, especially in the linker part (highlighted in orange).

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来源期刊
Angewandte Chemie
Angewandte Chemie 化学科学, 有机化学, 有机合成
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