Advancements in chemically inducible modified tRNA sequencing techniques: Elucidating novel insights into tRNA epitranscriptomics

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry Pub Date : 2025-02-26 DOI:10.1016/j.bmc.2025.118138

Xuan Li , Linqian Mu , Jiaying Liu , Kaidi Pengyang, Siqi Qin, Mingxing Zhou, Xiaoqian Chen, Yuyang Guo, Rui Wang

引用次数: 0

Abstract

In this review, we examine and expound upon the most recent and groundbreaking advancements in the sequencing of tRNA modifications, focusing specifically on the innovative chemical treatment approaches that have revolutionized this field. By delving into the intricate details of these cutting-edge methodologies, we aim to provide an overview of the current state of the art in tRNA modification sequencing, highlighting their unique strengths, limitations, and potential applications.

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化学诱导修饰tRNA测序技术的进展：阐明tRNA表转录组学的新见解

在这篇综述中，我们研究和阐述了tRNA修饰测序的最新和突破性进展，特别关注了革新这一领域的创新化学处理方法。通过深入研究这些前沿方法的复杂细节，我们旨在概述tRNA修饰测序的当前状态，突出其独特的优势，局限性和潜在的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.