MiR-326: Role and significance in brain cancers

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-coding RNA Research Pub Date : 2025-02-25 DOI:10.1016/j.ncrna.2025.02.006

Zaira Spinello , Zein Mersini Besharat , Fabrizio Mainiero , Aurelia Rughetti , Laura Masuelli , Elisabetta Ferretti , Giuseppina Catanzaro

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引用次数: 0

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that act as critical regulators of gene expression by repressing mRNA translation. The role of miRNAs in cell physiology spans from cell cycle control to cell proliferation and differentiation, both during development and in adult tissues. Accordingly, dysregulated expression of miRNAs has been reported in several diseases, including cancer, where miRNAs can act as oncogenes or oncosuppressors. Of note, miRNA signatures are also under investigation for classification, diagnosis, and prognosis of cancer patients.

Brain tumours are primarily associated with poor prognosis and high mortality, highlighting an urgent need for novel diagnostic, prognostic, and therapeutic tools. Among miRNAs investigated in brain tumours, miR-326 has been shown to act as a tumour suppressor in adult and paediatric brain cancers. In this review, we describe the role of miR-326 in malignant as well as benign cancers originating from brain tissue. In addition, since miR-326 expression can be regulated by other non-coding RNA species, adding a further layer of regulation in the cancer-promoting axis, we discuss this miRNA's role in targeted therapy for brain cancers.

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MiR-326在脑癌中的作用及意义

MicroRNAs （miRNAs）是一种小的非编码rna，通过抑制mRNA翻译作为基因表达的关键调节因子。mirna在细胞生理学中的作用涵盖从细胞周期控制到细胞增殖和分化，无论是在发育过程中还是在成年组织中。因此，在包括癌症在内的几种疾病中已经报道了miRNAs表达失调，其中miRNAs可以作为癌基因或癌抑制因子。值得注意的是，miRNA特征也在研究中用于癌症患者的分类、诊断和预后。脑肿瘤主要与预后差和高死亡率相关，因此迫切需要新的诊断、预后和治疗工具。在脑肿瘤中研究的mirna中，miR-326已被证明在成人和儿童脑癌中起肿瘤抑制作用。在这篇综述中，我们描述了miR-326在源自脑组织的恶性和良性癌症中的作用。此外，由于miR-326的表达可以受到其他非编码RNA物种的调控，从而在促癌轴上增加了一层调控，因此我们讨论了该miRNA在脑癌靶向治疗中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.