Catalytic Difunctionalization of Alkenes under Visible Light Irradiation: Synthesis of Iminofuranones

Abstract

Here, we show a cost-effective and environmentally friendly method for synthesizing iminofuranones using visible light and the photocatalyst 2-bromoanthraquinone. Our approach uses only oxygen as the oxidant, avoiding the need for additional transition metals and strong oxidizing agents. By employing a mixed solvent system of DMF and CHCl₃ under ambient conditions, we have achieved highly diastereoselective conversions of various 2-vinyl benzamides and alkenyl amides into functionalized iminoisobenzofuranones and iminofuranones. This versatile process is broadly applicable and enables late-stage structural modifications of complex substrates with bioactive moieties.