An Overview of Unlocking the Power of Non-Coding RNAs in Revolutionizing Cancer Therapy.

Sagarika Kabra, Neetu Sharma, Ankita Kumari, Saba Khan, Rashmi Pathak, Himanshu Sharma, Abdullah Al Noman
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Abstract

Non-coding RNA (ncRNA) has been recognized to be an essential regulator of cellular processes and gene expression in cancer. The present study covers the various roles of ncRNAs, including circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miR-NAs), that affect cancer properties. Oncogenesis, metastasis, and treatment resistance are all pro-cesses involving ncRNAs, which have tremendous potential as new therapeutic agents and tar-gets. The review covers the broad spectrum of ncRNAs in cancer biology, including their types and activities, epigenetic control, function in metastasis and angiogenesis, detection and profiling ap-proaches, potential as biomarkers, and therapeutic possibilities. Recent advancements in next-gener-ation sequencing and other molecular methods have helped us better understand how ncRNAs work and their potential therapeutic uses. However, there are still challenges to standardizing detection technologies and producing effective RNA-based therapeutics. Therefore, further studies are needed to solve important issues in this sector. Standardization efforts are also essential to developing iden-tical methods for ncRNA collection, quantification, and analysis throughout multiple laboratories and ensuring the findings are reliable and comparable. Large-scale, multi-recentre studies are required to verify the diagnostic usefulness of ncRNA biomarkers across a wide range of patient groups. Also, more detailed mechanistic knowledge is necessary for understanding the particular molecular mech-anisms by which ncRNAs affect cancer growth, metastasis, and treatment response. This review high-lights the complex relationships between ncRNAs and cancer biology and also focuses on their po-tential effect on cancer diagnosis and treatment. It also highlights the necessity for more studies to fully understand the therapeutic potential of ncRNAs in cancer. As studies advance, using ncRNA results in clinical practice might change cancer treatment by novel opportunities for specific therapy and personalized medicine.

非编码rna在癌症治疗中的革命性作用综述
非编码RNA (ncRNA)已被认为是肿瘤细胞过程和基因表达的重要调节因子。本研究涵盖了ncRNAs的各种作用,包括影响癌症特性的环状rna (circRNAs)、长链非编码rna (lncRNAs)和微rna (miR-NAs)。肿瘤发生、转移、耐药等过程均与ncrna有关,作为新的治疗药物和靶点具有巨大的潜力。这篇综述涵盖了肿瘤生物学中广泛的ncrna,包括它们的类型和活性、表观遗传控制、在转移和血管生成中的功能、检测和分析方法、作为生物标志物的潜力和治疗可能性。新一代测序和其他分子方法的最新进展帮助我们更好地了解ncrna的工作原理及其潜在的治疗用途。然而,在标准化检测技术和生产有效的基于rna的治疗方法方面仍然存在挑战。因此,需要进一步的研究来解决这一领域的重要问题。标准化工作对于在多个实验室中开发相同的ncRNA收集、定量和分析方法以及确保结果的可靠性和可比性也至关重要。需要大规模的、多中心的研究来验证ncRNA生物标志物在广泛的患者群体中的诊断作用。此外,更详细的机制知识对于理解ncrna影响肿瘤生长、转移和治疗反应的特定分子机制是必要的。这篇综述强调了ncrna与癌症生物学之间的复杂关系,以及它们在癌症诊断和治疗中的潜在作用。这也强调了需要更多的研究来充分了解ncrna在癌症中的治疗潜力。随着研究的推进,在临床实践中使用ncRNA结果可能会为特异性治疗和个性化医疗提供新的机会,从而改变癌症治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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