Innovative Horizons in Drug Design: Exploring the Synthesis and Medicinal Properties of Heterocyclic Schiff Bases. A Review.

IF 3.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Mini reviews in medicinal chemistry Pub Date : 2025-02-26 DOI:10.2174/0113895575320413250126041041

Yousaf Khan, Hina Sarfraz, Wajid Rehman, Momin Khan, Liaqat Rasheed, Khursheed Ur Rahman

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Abstract

Schiff bases are an important scaffold for designing drug development. They are characterized by having a carbon-nitrogen double bond. This double bond is synthesized by different synthetic schemes by both the aromatic and aliphatic chains. Bases inspired chemists due to their versatile importance in drug discovery and drug development. A large number of drugs are designed through the heterocyclic Schiff base moieties. This review highlighted the importance of Schiff bases concerning their bioactive importance in drug design. Moreover, amide-iminol tautomerism is a significant tool for the high biological importance of Schiff bases due to the presence of the C=N bond. Furthermore, the reported synthesized heterocyclic scaffolds Schiff bases have a wide range of biological importance. Due to this different biological importance, such as antimicrobial, anticonvulsant, analgesic, antioxidant, antimalarial, anti-inflammatory, anticancer, antidiabetic, and antileishmanial properties, the researcher has shown their interest by synthesizing different heterocyclic Schiff bases. In this review article, biologically active heterocyclic Schiff bases were reviewed intensively concerning drug design and drug development.

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药物设计的创新视野：探索杂环席夫碱的合成和药性。复习一下。

希夫碱基是设计药物开发的重要支架。它们的特点是有碳氮双键。这个双键由芳香链和脂肪链通过不同的合成方案合成。由于碱基在药物发现和药物开发中具有广泛的重要性，因此激发了化学家的灵感。大量的药物是通过杂环希夫碱部分设计的。本文综述了希夫碱在药物设计中的生物活性重要性。此外，由于C=N键的存在，酰胺亚胺互变异构是希夫碱具有高生物学重要性的重要工具。此外，所合成的杂环席夫碱支架具有广泛的生物学意义。由于这种不同的生物学重要性，如抗菌、抗惊厥、镇痛、抗氧化、抗疟疾、抗炎、抗癌、抗糖尿病和抗利什曼原虫的性质，研究人员通过合成不同的杂环希夫碱来显示他们的兴趣。本文就生物活性杂环希夫碱在药物设计和药物开发方面的研究进展进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mini reviews in medicinal chemistry 医学-医药化学

CiteScore

7.80

自引率

0.00%

发文量

231

审稿时长

6 months

期刊介绍： The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.