Gymnopeptides C and D, Highly N-Methylated Fungal Cyclopeptides.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-03-28 Epub Date: 2025-02-27 DOI:10.1021/acs.jnatprod.4c01132

Márton Weber, Miklós Dékány, Andrea Nedves Nagyné, Csenge Anna Felegyi-Tóth, Suratno Suratno, Balázs Krámos, Enikő Bodó, Zoltán Béni, Attila Ványolós

引用次数: 0

Abstract

An in-depth chemical study of the fungus Gymnopus fusipes led to the discovery of two new cyclooctadecapeptides, gymnopeptides C and D, besides the known gymnopeptides A and B. Spectroscopic studies, as well as Marfey's analysis, and molecular modeling studies revealed the characteristic structural features of these cyclopeptides. Gymnopeptides A-D demonstrated antiproliferative activity on the A375 human cancer cell line, induced apoptosis by upregulation of caspase-3 activity, and acted as a suppressor of cell migration.

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.