{"title":"A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC","authors":"Daniel St Johnston","doi":"10.1038/s41594-025-01506-8","DOIUrl":null,"url":null,"abstract":"The apical–basal polarity of epithelial cells depends on mutual antagonism between the apical aPKC and lateral LGL proteins. Until now, it has been unclear how LGL can be both a substrate and inhibitor of aPKC. Now, a cryo-electron microscopy (cryo-EM) structure of a stalled PAR6–aPKC–LGL complex addresses this conundrum.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01506-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The apical–basal polarity of epithelial cells depends on mutual antagonism between the apical aPKC and lateral LGL proteins. Until now, it has been unclear how LGL can be both a substrate and inhibitor of aPKC. Now, a cryo-electron microscopy (cryo-EM) structure of a stalled PAR6–aPKC–LGL complex addresses this conundrum.
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