{"title":"mSphere of Influence: The maternal gut-mammary axis and its role in shaping neonatal health.","authors":"Stephanie N Langel","doi":"10.1128/msphere.00556-24","DOIUrl":null,"url":null,"abstract":"<p><p>Stephanie Langel works in the field of breast milk immunity and maternal-neonatal health. In this mSphere of Influence article, she reflects on how three pivotal papers-Roux et al. (J Exp Med 146:1311-1322, 1977, https://doi.org/10.1084/jem.146.5.1311), Wilson and Butcher (J Exp Med 200:805-809, 2004, https://doi.org/10.1084/jem.20041069), and Rogier et al. (Proc Natl Acad Sci USA 111:3074-3079, 2014, https://doi.org/10.1073/pnas.1315792111)-made an impact on her by uncovering the critical pathways and mechanisms through which gut-derived IgA-secreting cells migrate to the mammary gland and secrete antibodies against intestinal microbes. These foundational studies shaped her understanding of the gut-mammary axis and continue to inspire her research aimed at advancing maternal and neonatal health through breast milk immunology.</p>","PeriodicalId":19052,"journal":{"name":"mSphere","volume":" ","pages":"e0055624"},"PeriodicalIF":3.7000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934305/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"mSphere","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1128/msphere.00556-24","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/26 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Stephanie Langel works in the field of breast milk immunity and maternal-neonatal health. In this mSphere of Influence article, she reflects on how three pivotal papers-Roux et al. (J Exp Med 146:1311-1322, 1977, https://doi.org/10.1084/jem.146.5.1311), Wilson and Butcher (J Exp Med 200:805-809, 2004, https://doi.org/10.1084/jem.20041069), and Rogier et al. (Proc Natl Acad Sci USA 111:3074-3079, 2014, https://doi.org/10.1073/pnas.1315792111)-made an impact on her by uncovering the critical pathways and mechanisms through which gut-derived IgA-secreting cells migrate to the mammary gland and secrete antibodies against intestinal microbes. These foundational studies shaped her understanding of the gut-mammary axis and continue to inspire her research aimed at advancing maternal and neonatal health through breast milk immunology.
期刊介绍：
mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.
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