Effect of Composition on the Thermo-Induced Aggregation of Poloxamer-Analogue Triblock Terpolymers

IF 5.1 1区化学 Q1 POLYMER SCIENCE

Macromolecules Pub Date : 2025-02-26 DOI:10.1021/acs.macromol.4c02217

Shaobai Wang, Alberto Alvarez-Fernandez, Xu Liu, Sofia Miron-Barroso, Kelvin Wong, Stefan Guldin, Theoni K. Georgiou

{"title":"Effect of Composition on the Thermo-Induced Aggregation of Poloxamer-Analogue Triblock Terpolymers","authors":"Shaobai Wang, Alberto Alvarez-Fernandez, Xu Liu, Sofia Miron-Barroso, Kelvin Wong, Stefan Guldin, Theoni K. Georgiou","doi":"10.1021/acs.macromol.4c02217","DOIUrl":null,"url":null,"abstract":"Thermoresponsive polymers hold great promise for biomedical applications due to their thermo-induced phase transitions. However, challenges including controlling transition temperatures, aggregate behavior, or complex synthesis, have limited their broader use. In this study, six ABC triblock terpolymers were synthesized via group transfer polymerization, targeting a molar mass of 8000 g/mol with varying compositions. The terpolymers consist of hydrophilic oligo(ethylene glycol) methyl ether methacrylate (average molar mass = 300 g/mol, OEGMA300), hydrophobic di(propylene glycol) methyl ether methacrylate (diPGMA), and less-hydrophilic di(ethylene glycol) methyl ether methacrylate (DEGMA). Systematic characterizations of properties related to thermo-induced aggregation, including cloud point temperature, aggregate morphology, and chain immobilization, identified a unique dual-stage phase transition in the terpolymer containing 45 wt % OEGMA300, 35 wt % diPGMA, and 20 wt % DEGMA. Instead of directly agglomerating into globular aggregates, this terpolymer transitioned from spherical micelles to vesicular species, offering valuable insights for the design of controllable and responsive polymer systems.","PeriodicalId":51,"journal":{"name":"Macromolecules","volume":"7 1","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecules","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.macromol.4c02217","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}

引用次数: 0

Abstract

Thermoresponsive polymers hold great promise for biomedical applications due to their thermo-induced phase transitions. However, challenges including controlling transition temperatures, aggregate behavior, or complex synthesis, have limited their broader use. In this study, six ABC triblock terpolymers were synthesized via group transfer polymerization, targeting a molar mass of 8000 g/mol with varying compositions. The terpolymers consist of hydrophilic oligo(ethylene glycol) methyl ether methacrylate (average molar mass = 300 g/mol, OEGMA300), hydrophobic di(propylene glycol) methyl ether methacrylate (diPGMA), and less-hydrophilic di(ethylene glycol) methyl ether methacrylate (DEGMA). Systematic characterizations of properties related to thermo-induced aggregation, including cloud point temperature, aggregate morphology, and chain immobilization, identified a unique dual-stage phase transition in the terpolymer containing 45 wt % OEGMA300, 35 wt % diPGMA, and 20 wt % DEGMA. Instead of directly agglomerating into globular aggregates, this terpolymer transitioned from spherical micelles to vesicular species, offering valuable insights for the design of controllable and responsive polymer systems.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Macromolecules 工程技术-高分子科学

CiteScore

9.30

自引率

16.40%

发文量

942

审稿时长

2 months

期刊介绍： Macromolecules publishes original, fundamental, and impactful research on all aspects of polymer science. Topics of interest include synthesis (e.g., controlled polymerizations, polymerization catalysis, post polymerization modification, new monomer structures and polymer architectures, and polymerization mechanisms/kinetics analysis); phase behavior, thermodynamics, dynamic, and ordering/disordering phenomena (e.g., self-assembly, gelation, crystallization, solution/melt/solid-state characteristics); structure and properties (e.g., mechanical and rheological properties, surface/interfacial characteristics, electronic and transport properties); new state of the art characterization (e.g., spectroscopy, scattering, microscopy, rheology), simulation (e.g., Monte Carlo, molecular dynamics, multi-scale/coarse-grained modeling), and theoretical methods. Renewable/sustainable polymers, polymer networks, responsive polymers, electro-, magneto- and opto-active macromolecules, inorganic polymers, charge-transporting polymers (ion-containing, semiconducting, and conducting), nanostructured polymers, and polymer composites are also of interest. Typical papers published in Macromolecules showcase important and innovative concepts, experimental methods/observations, and theoretical/computational approaches that demonstrate a fundamental advance in the understanding of polymers.