Sexual dimorphism in pituitary neuroendocrine tumours

IF 40 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature Reviews Endocrinology Pub Date : 2025-02-25 DOI:10.1038/s41574-025-01096-x

Shaojian Lin (, ), Jun Li (, ), Zhe Bao Wu (, )

引用次数: 0

Abstract

Pituitary neuroendocrine tumours (PitNETs) exhibit notable sex-related differences, particularly in prolactinomas and corticotroph tumours. Findings from the past 5 years in other cancers suggest that interactions between sex hormones and the immune system, as well as epigenetic modifications specific to sex chromosomes, could influence sex differences in tumour development.

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垂体神经内分泌肿瘤的两性二态性

垂体神经内分泌肿瘤（PitNETs）表现出显著的性别相关差异，特别是在催乳素瘤和促皮质性肿瘤中。过去5年对其他癌症的研究表明，性激素和免疫系统之间的相互作用，以及性染色体特异性的表观遗传修饰，可能会影响肿瘤发展中的性别差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Endocrinology 医学-内分泌学与代谢

CiteScore

42.00

自引率

0.70%

发文量

158

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.