{"title":"Monoterpenoid indole alkaloids from the stems and leaves of <i>Tabernaemontana bovina</i> and their potential antiproliferative activities.","authors":"Shu-Ri Li, Xiao-Ya Fu, Ye-Ping Liu, Rui Qiu, Bing-Yan Sun, Jing-Su Yu, An-Jiao Wu, Hui Yang, Yan-Ping Liu, Yan-Hui Fu","doi":"10.1080/10286020.2025.2459604","DOIUrl":null,"url":null,"abstract":"<p><p>A phytochemical study on the stems and leaves of <i>Tabernaemontana bovina</i> led to the isolation and identification of a new monoterpenoid indole alkaloid, taberboviline (<b>1</b>), together with seven known monoterpenoid indole alkaloids (2-8). The chemical structure of <b>1</b> was elucidated on the basis of extensive spectral data analyses and the known compounds were identified by comparing their experimental spectral data with the reported data in the literature. All isolated indole alkaloids were evaluated for their antiproliferative activities against five human cancer cell lines <i>in vitro</i>. Monoterpenoid indole alkaloids <b>1</b>-<b>8</b> exhibited notable antiproliferative activities against five human cancer cell lines with IC<sub>50</sub> values ranging from 0.58 ± 0.05 to 26.19 ± 0.16 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2025.2459604","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
A phytochemical study on the stems and leaves of Tabernaemontana bovina led to the isolation and identification of a new monoterpenoid indole alkaloid, taberboviline (1), together with seven known monoterpenoid indole alkaloids (2-8). The chemical structure of 1 was elucidated on the basis of extensive spectral data analyses and the known compounds were identified by comparing their experimental spectral data with the reported data in the literature. All isolated indole alkaloids were evaluated for their antiproliferative activities against five human cancer cell lines in vitro. Monoterpenoid indole alkaloids 1-8 exhibited notable antiproliferative activities against five human cancer cell lines with IC50 values ranging from 0.58 ± 0.05 to 26.19 ± 0.16 μM.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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