Maternal and Fetal Implications of Oropouche Fever, Espírito Santo State, Brazil, 2024

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-02-24 DOI:10.3201/eid3104.241986

João Paulo Cola, Ana Paula Brioschi dos Santos, Raphael Lubiana Zanotti, Adriana Endlich da Silva Dela Costa, Karina Bertazo Del Carro, Lesliane de Amorim Lacerda Coelho, Angelica Espinosa Miranda, Creuza Rachel Vicente

{"title":"Maternal and Fetal Implications of Oropouche Fever, Espírito Santo State, Brazil, 2024","authors":"João Paulo Cola, Ana Paula Brioschi dos Santos, Raphael Lubiana Zanotti, Adriana Endlich da Silva Dela Costa, Karina Bertazo Del Carro, Lesliane de Amorim Lacerda Coelho, Angelica Espinosa Miranda, Creuza Rachel Vicente","doi":"10.3201/eid3104.241986","DOIUrl":null,"url":null,"abstract":"<p>Reemergence of Oropouche fever in Brazil raises concerns about potential risks for infection in pregnancy. We describe a case series of Oropouche fever in pregnant women and their neonates in Espírito Santo State, Brazil, in 2024. Of 73 pregnancies, 15 pregnancies concluded by the end of the study period; of those, 14 resulted in live births and 1 in spontaneous abortion. Placental reverse transcription PCR tests were positive for Oropouche virus RNA in 5 infections in the third trimester. Two infections occurred in the first trimester, resulting in 1 spontaneous abortion and 1 live birth with corpus callosum dysgenesis. Of 13 infections that occurred in the third trimester, 1 showed possible intrapartum transmission with clinical manifestations in the neonate, whereas the others were asymptomatic. We found no anomalies in third-trimester infections. These findings suggest possible vertical transmission of Oropouche virus and a potential link with spontaneous abortion or malformation.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"53 1","pages":""},"PeriodicalIF":7.2000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Emerging Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3201/eid3104.241986","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Reemergence of Oropouche fever in Brazil raises concerns about potential risks for infection in pregnancy. We describe a case series of Oropouche fever in pregnant women and their neonates in Espírito Santo State, Brazil, in 2024. Of 73 pregnancies, 15 pregnancies concluded by the end of the study period; of those, 14 resulted in live births and 1 in spontaneous abortion. Placental reverse transcription PCR tests were positive for Oropouche virus RNA in 5 infections in the third trimester. Two infections occurred in the first trimester, resulting in 1 spontaneous abortion and 1 live birth with corpus callosum dysgenesis. Of 13 infections that occurred in the third trimester, 1 showed possible intrapartum transmission with clinical manifestations in the neonate, whereas the others were asymptomatic. We found no anomalies in third-trimester infections. These findings suggest possible vertical transmission of Oropouche virus and a potential link with spontaneous abortion or malformation.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.