Antioxidant and Anti-Inflammatory Constituents from Myristica elliptica var. simiarum

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-02-05 DOI:10.1007/s10600-025-04568-8

Chih-Hui Chin, Zih-Rong Chen, Tsung-Hsien Chang, Chia-Ching Liaw, Ping-Jyun Sung, Ming-Jen Cheng, Chien-Ming Huang, Jih-Jung Chen

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Abstract

A new neolignan derivative, myrisellipin (1), has been isolated from the seeds of Myristica elliptica var. simiarum, together with seven known compounds, licarin A (2), accuminatin (3), butein (4), 3′-hydroxypterostilbene (5), malabaricone B (6), malabaricone C (7), and 3-(3,4,5-trimethoxyphenyl)-2-(E)-propen-1-ol (8). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, 1, 4, 5, 7, 8 showed potent inhibition, with IC₅₀ values of 16.83 ± 1.18, 17.92 ± 1.28, 25.06 ± 2.01, 22.05 ± 1.74, and 23.58 ± 1.96 μM respectively, against LPS-induced NO generation. In addition, compounds 4, 5, and 8 also showed potent DPPH radical scavenging activities, with IC₅₀ values of 37.02 ± 2.89, 80.36 ± 5.78, and 50.07 ± 4.11 μM, respectively.

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椭圆肉豆蔻抗氧化和抗炎成分的研究

从Myristica elliptica vart . similarum种子中分离到一种新的木聚糖衍生物myrisellipin(1)，并分离到licarin A(2)、accuminatin(3)、butyin(4)、3′-羟基苯乙烯(5)、malabaricone B(6)、malabaricone C(7)和3-（3,4,5-三甲氧基苯基）-2-(E)-丙烯-1-ol(8)等7个已知化合物。其中化合物1、4、5、7、8对lps诱导的NO生成具有较强的抑制作用，IC50值分别为16.83±1.18、17.92±1.28、25.06±2.01、22.05±1.74和23.58±1.96 μM。此外，化合物4、5和8也具有较强的DPPH自由基清除活性，IC50值分别为37.02±2.89 μM、80.36±5.78 μM和50.07±4.11 μM。

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.