Xin-Yao Huang, Jin-Yun Liu, Jin Wang, Li-Ying Yang, Chong-Jun Xu, Kua-Ping Wang, Guang-Yu Yang, Qiu-Fen Hu, Shi-Tao Xu, Hua-Yin Liu
{"title":"Two New Aromatic Sesquiterpenes from Tobacco Flower Extract and Their Antibacterial Activity","authors":"Xin-Yao Huang, Jin-Yun Liu, Jin Wang, Li-Ying Yang, Chong-Jun Xu, Kua-Ping Wang, Guang-Yu Yang, Qiu-Fen Hu, Shi-Tao Xu, Hua-Yin Liu","doi":"10.1007/s10600-025-04582-w","DOIUrl":null,"url":null,"abstract":"<p>Two new aromatic sesquiterpenes, nicosesquites C and D (<b>1</b> and <b>2</b>), as well as five known sesquiterpenes (<b>3–7</b>), were isolated from tobacco flower extract. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> were tested for their antibacterial activity against five pathogenic strains (<i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Streptococcus pyogenes</i>, <i>Bacillus subtilis</i>, and <i>Proteus</i> spp.). The results revealed that both compounds showed high antibacterial activity with bacteriostatic diameters in the range of 18.2 ± 1.4~25.8 ± 2.2 mm, respectively. In addition, compounds <b>1</b> and <b>2</b> also have a weak resin-like aroma, and they have potential value for use as an essence for cigarettes.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 1","pages":"91 - 95"},"PeriodicalIF":0.8000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04582-w","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Two new aromatic sesquiterpenes, nicosesquites C and D (1 and 2), as well as five known sesquiterpenes (3–7), were isolated from tobacco flower extract. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their antibacterial activity against five pathogenic strains (Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Bacillus subtilis, and Proteus spp.). The results revealed that both compounds showed high antibacterial activity with bacteriostatic diameters in the range of 18.2 ± 1.4~25.8 ± 2.2 mm, respectively. In addition, compounds 1 and 2 also have a weak resin-like aroma, and they have potential value for use as an essence for cigarettes.
期刊介绍:
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.