Perilesional Enhancement: A Valuable Feature for Differentiation of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma in CEUS LI-RADS M.

IF 3.8 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Academic Radiology Pub Date : 2025-02-20 DOI:10.1016/j.acra.2024.12.071

Xia Meng, Ye Yun, Wei Jiang, Yu-Wen Bi, Ting Dai, Zhi-Xia Sun

{"title":"Perilesional Enhancement: A Valuable Feature for Differentiation of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma in CEUS LI-RADS M.","authors":"Xia Meng, Ye Yun, Wei Jiang, Yu-Wen Bi, Ting Dai, Zhi-Xia Sun","doi":"10.1016/j.acra.2024.12.071","DOIUrl":null,"url":null,"abstract":"Rationale and objectives: We investigated whether the peritumoral enhancement feature can aid in discriminating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC) in contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System M (LR-M).Materials and methods: Between May 2018 and July 2024, 147 LR-M and 320 LR-5. lesions with pathologically confirmed HCC and ICC diagnoses after CEUS were examined. We evaluated the diagnostic efficacy of HCC with different diameters (≤3, 3-5, and 5-7cm) in the LR-M by peritumoral enhancement. We analysed the correlation between pathological perilesional hepatic sinusoid vessels and perilesional enhancement on CEUS in LR-M. The diagnostic performance of LR-5 with and without perilesional enhancement was evaluated.Results: There were 93/107 HCC lesions and 1/40 ICC lesion with perilesional hepatic sinusoid vessels in LR-M. CEUS revealed perilesional enhancement in 81.31% (87/107) of HCC lesions and 10.00% (4/40) of ICC lesions. There was a correlation between perilesional hepatic sinusoid vessel and perilesional enhancement with correlation coefficients of 0.738. The diagnostic efficacy of 5-7cm lesions was the best, and the sensitivity, specificity, accuracy, and AUC were 0.900, 0.864, 0.885, and 0.882. After perilesional enhancement was added to LR-5, 91 cases of HCC in LR-M were adjusted into LR-5. The adjusted diagnostic efficacy was significantly improved.Conclusion: Perilesional enhancement on CEUS correlates with perilesional hepatic sinusoid vessel. Perilesional enhancement is a valuable feature for distinguishing HCC and ICC and could be added as a feature in CEUS LI-RADS.","PeriodicalId":50928,"journal":{"name":"Academic Radiology","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Academic Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.acra.2024.12.071","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Rationale and objectives: We investigated whether the peritumoral enhancement feature can aid in discriminating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC) in contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System M (LR-M).

Materials and methods: Between May 2018 and July 2024, 147 LR-M and 320 LR-5. lesions with pathologically confirmed HCC and ICC diagnoses after CEUS were examined. We evaluated the diagnostic efficacy of HCC with different diameters (≤3, 3-5, and 5-7cm) in the LR-M by peritumoral enhancement. We analysed the correlation between pathological perilesional hepatic sinusoid vessels and perilesional enhancement on CEUS in LR-M. The diagnostic performance of LR-5 with and without perilesional enhancement was evaluated.

Results: There were 93/107 HCC lesions and 1/40 ICC lesion with perilesional hepatic sinusoid vessels in LR-M. CEUS revealed perilesional enhancement in 81.31% (87/107) of HCC lesions and 10.00% (4/40) of ICC lesions. There was a correlation between perilesional hepatic sinusoid vessel and perilesional enhancement with correlation coefficients of 0.738. The diagnostic efficacy of 5-7cm lesions was the best, and the sensitivity, specificity, accuracy, and AUC were 0.900, 0.864, 0.885, and 0.882. After perilesional enhancement was added to LR-5, 91 cases of HCC in LR-M were adjusted into LR-5. The adjusted diagnostic efficacy was significantly improved.

Conclusion: Perilesional enhancement on CEUS correlates with perilesional hepatic sinusoid vessel. Perilesional enhancement is a valuable feature for distinguishing HCC and ICC and could be added as a feature in CEUS LI-RADS.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.