A model that integrates the different piRNA biogenesis pathways based on studies in silkworm BmN4 cells

IF 2.2 Q1 ENTOMOLOGY
Thomas-Wolf Verdonckt , Luc Swevers , Dulce Santos
{"title":"A model that integrates the different piRNA biogenesis pathways based on studies in silkworm BmN4 cells","authors":"Thomas-Wolf Verdonckt ,&nbsp;Luc Swevers ,&nbsp;Dulce Santos","doi":"10.1016/j.cris.2025.100108","DOIUrl":null,"url":null,"abstract":"<div><div>PIWI-interacting (pi) RNAs play an essential role in protecting the genomic integrity of germ cells from the disruptive transpositions of selfish genetic elements. One of the most important model systems for studying piRNA biogenesis is the ovary derived BmN4 cell line of the silkworm Bombyx mori. In recent years, many steps and components of the pathways involved in this process have been unraveled. However, a holistic description of piRNA biogenesis in BmN4 cells is still unavailable. In this paper, we review the state of the art and propose a novel model for piRNA biogenesis in BmN4 cells. This model was built considering the latest published data and will empower researchers to plan future experiments and interpret experimental results.</div></div>","PeriodicalId":34629,"journal":{"name":"Current Research in Insect Science","volume":"7 ","pages":"Article 100108"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Research in Insect Science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666515825000034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENTOMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

PIWI-interacting (pi) RNAs play an essential role in protecting the genomic integrity of germ cells from the disruptive transpositions of selfish genetic elements. One of the most important model systems for studying piRNA biogenesis is the ovary derived BmN4 cell line of the silkworm Bombyx mori. In recent years, many steps and components of the pathways involved in this process have been unraveled. However, a holistic description of piRNA biogenesis in BmN4 cells is still unavailable. In this paper, we review the state of the art and propose a novel model for piRNA biogenesis in BmN4 cells. This model was built considering the latest published data and will empower researchers to plan future experiments and interpret experimental results.
基于家蚕BmN4细胞研究的不同piRNA生物发生途径整合模型
piwi相互作用(pi) rna在保护生殖细胞基因组完整性免受自私遗传元件的破坏性转位方面发挥着重要作用。家蚕子房源性BmN4细胞系是研究piRNA生物发生最重要的模型系统之一。近年来,这一过程中涉及的许多步骤和途径的组成部分已被解开。然而,关于piRNA在BmN4细胞中的生物发生的整体描述仍然是不可用的。在本文中,我们回顾了目前的研究现状,并提出了一种新的BmN4细胞中piRNA生物发生的模型。该模型是根据最新公布的数据建立的,将使研究人员能够计划未来的实验并解释实验结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Current Research in Insect Science
Current Research in Insect Science Agricultural and Biological Sciences-Animal Science and Zoology
CiteScore
3.20
自引率
0.00%
发文量
22
审稿时长
36 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信