Allicin protects against pancreatic damage induced by zearalenone in rats by inhibiting endoplasmic reticulum stress

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2025-02-19 DOI:10.1016/j.tice.2025.102802

Amany Mohamed Shalaby , Amira Mostafa Elshamy , Abdulfatah Mohammed Albakkosh , Sulaiman Mohammed Alnasser , Mohammed Alorini , Fatima A. Jaber , Mohamed Ali Alabiad , Sabah Mohamed Hanafy , Nema Soliman , Shereen Elsayed Tawfeek

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引用次数: 0

Abstract

Zearalenone (ZEL) is a mycotoxin generated by Fusarium fungus. Ingestion of ZEL-contaminated foods by humans or animals can cause major health concerns. This work assessed the protective role of allicin in mitigating pancreatic damage caused by ZEL in rats. The experimental rats were allocated into control, Allicin (45 mg/kg /day), ZEL (20 mg/kg/ day), and Allicin-ZEL groups. The agents were administered orally for six weeks. ZEL enhanced the serum levels of amylase and lipase, oxidative stress parameters, and endoplasmic reticulum (ER) stress biomarkers, along with a marked decrease in the serum level of insulin. The disturbed architecture of pancreatic acini was demonstrated in the form of vacuolation of acini, degenerated acini with pyknotic nuclei, and infiltration around dilated congested blood vessels, in addition to the presence of dilated intralobular ducts with retained secretions. Also, the islet of Langerhans cells showed vacuolation and darkly stained nuclei. Immunohistochemically, a marked rise in the expression of heat shock protein 70 (HSP70) and P53 and a marked decline in insulin expression were demonstrated. Ultrastructurally, the pancreatic acinar cells and islets of Langerhans cells displayed shrunken irregular nuclei with dilated perinuclear cisternae and dilated rER. Interestingly, co-administration of allicin and ZEL greatly mitigated these detrimental effects. In summary, allicin inhibited pancreatic injury induced by ZEL by decreasing oxidative stress, ER stress, and apoptosis.

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.