A complete set of rate constants for a transporter's catalytic cycle.

IF 3.3 2区医学 Q1 PHYSIOLOGY

Journal of General Physiology Pub Date : 2025-05-05 Epub Date: 2025-02-21 DOI:10.1085/jgp.202513766

Michael L Jennings

引用次数: 0

Abstract

The article by Lewis et al. (https://doi.org/10.1085/jgp.202413709) in this issue of JGP describes the use of single-molecule fluorescence polarization microscopy to obtain estimates of all the rate constants for transitions in the catalytic cycle of AdiC, a bacterial transporter for arginine and agmatine that has been believed to be a 1:1 exchanger.

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转运体催化循环的一整套速率常数。

Lewis等人（https://doi.org/10.1085/jgp.202413709）在本期《JGP》上发表的文章描述了使用单分子荧光偏振显微镜来估计AdiC催化循环中所有转变的速率常数。AdiC是一种细菌的精氨酸和agmatine转运体，被认为是1:1的交换剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of General Physiology 医学-生理学

CiteScore

6.00

自引率

10.50%

发文量

审稿时长

6-12 weeks

期刊介绍： General physiology is the study of biological mechanisms through analytical investigations, which decipher the molecular and cellular mechanisms underlying biological function at all levels of organization. The mission of Journal of General Physiology (JGP) is to publish mechanistic and quantitative molecular and cellular physiology of the highest quality, to provide a best-in-class author experience, and to nurture future generations of independent researchers. The major emphasis is on physiological problems at the cellular and molecular level.