Correlation of the theory of mind damage and brain imaging in adolescent depressed patients with suicide attempt: A case control study

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2025-02-12 DOI:10.1016/j.pscychresns.2025.111962

Mengting Li , Yue Yang , Hongyu Zheng , Daming Mo , Xiaofei Wen , Longxing Liu , Xiaolu Jiang , Hui Zhong

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Abstract

Objective

To investigate the correlation between the theory of mind and the amplitude difference of low-frequency fluctuations in resting-state fMRI.

Methods

This study included 38 depressed adolescents who had attempted suicide (SU group), 53 depressed patients who had not attempted suicide (NSU group), and 20 healthy controls (HC group). All participants used the 17-item Hamilton Depression Scale. The low-frequency fluctuation amplitude (zALFF) values were calculated using resting-state functional magnetic resonance imaging and compared between the groups. The theory of mind story picture task (theory of mind-picture sequencing task, ToM-PST) were used to test the psychological theory level of the three groups. Statistical analysis of the data was performed using SPSS 25.0. One-way ANOVA was used to compare the differences between the three groups. Pearson correlation analysis was used to explore the correlation between zALFF values and psychological theoretical damage in specific brain regions.

Results

Significant zALFF values were found between the three groups (GRF correction), with decreased zALFF values in both the SU and NSU groups compared to HC. In the adolescent SU group, the primary belief, primary false belief, and deception scores were significantly higher than those in the NSU group. The primary false belief, reality, and deception detection scores were significantly lower than those in the HC group (all P < 0. 05). Pearson Correlation analysis showed that the zALFF value of the left dorsolateral superior frontal gyrus was significantly negatively correlated with secondary false beliefs, reciprocity, and the total score. (all P < 0.05).

Conclusion

Juvenile patients with depressive disorder with suicide attempts showed an ability to understand secondary false beliefs, reciprocity, and total scores. This ability showed a significant negative correlation with low-frequency fluctuation amplitude values in the left dorsolateral superior frontal gyri.

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自杀未遂青少年抑郁症患者精神损伤理论与脑成像的相关性：病例对照研究

目的探讨心理理论与静息状态fMRI低频波动幅度差的相关性。方法选取38例自杀未遂的抑郁青少年（SU组）、53例未自杀未遂的抑郁患者（NSU组）和20例健康对照（HC组）。所有参与者都使用了17项汉密尔顿抑郁量表。静息状态功能磁共振成像计算各组低频波动幅度（zALFF）值，并进行组间比较。采用心理故事图理论任务（theory of mind-picture sequencing task, ToM-PST）测试三组学生的心理理论水平。数据采用SPSS 25.0进行统计分析。采用单因素方差分析比较三组间的差异。采用Pearson相关分析探讨zALFF值与特定脑区心理理论损伤的相关性。结果三组间zALFF值显著（GRF校正），SU组和NSU组zALFF值均低于HC组。初中生组的初级信念、初级错误信念和欺骗得分显著高于初中生组。初级错误信念、真实性和欺骗检测得分显著低于HC组(P <；0. 05)。Pearson相关分析显示，左背外侧额上回zALFF值与次级错误信念、互惠性、总分呈显著负相关。(全部P <；0.05)。结论青少年自杀未遂抑郁症患者具有次级错误信念、互惠性和总分的理解能力。这种能力与左背外侧额上回低频波动幅度值呈显著负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.