Study on the Effect of Lesion Volume and Focal Temperature Caused by HIFU Combined with Different Concentrations and Volumes of Ethanol on Porcine Liver.

Q3 Medicine
Hu Dong, Jiwen Hu, Xiao Zou, Wei Chen
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引用次数: 0

Abstract

Background: High-intensity Focused Ultrasound (HIFU) is a rapidly developing non-invasive treatment method for tumors in recent years.

Objective: The present study aimed to investigate the lesion and temperature effects of HIFU combined with different concentrations and volumes of ethanol on porcine liver.

Material and methods: In this experimental study, different concentrations and volumes of ethanol were injected into the focal area of porcine liver using B-mode ultrasound, and the focal temperature was monitored using a k-type needle thermocouple. The peak negative pressure and sound intensity at the focal point of porcine liver were calculated by Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation. Further, the presence of cavitation effects within porcine liver was further determined by ultrasound hyperechoic. The differences in lesion volume and temperature, caused by different concentrations and volumes of ethanol on porcine liver, were measured.

Results: HIFU irradiation combined with ethanol injection caused greater lesion volume and higher focal temperature in porcine liver. At the same HIFU irradiation power, an increase in the volume of ethanol resulted in an increase in lesion volume and focal temperature. At a fixed volume of ethanol injected and HIFU irradiation power, higher ethanol concentrations resulted in higher lesion volumes and focal temperature.

Conclusion: The combination of HIFU and ethanol synergistically affects the lesion of porcine liver, manifested as the larger the ethanol concentration and volume, the larger the lesion volume and the higher the focal temperature.

HIFU联合不同浓度和体积乙醇对猪肝脏损伤体积和病灶温度影响的研究。
背景:高强度聚焦超声(High-intensity Focused Ultrasound, HIFU)是近年来发展迅速的一种非侵入性肿瘤治疗方法。目的:探讨HIFU联合不同浓度和体积乙醇对猪肝脏损伤及温度的影响。材料与方法:本实验研究采用b超将不同浓度和体积的乙醇注射到猪肝病灶区域,并采用k型针热电偶监测病灶温度。采用Khokhlov-Zabolotskaya-Kuznetsov (KZK)方程计算猪肝焦点处的峰值负压和声强。此外,通过超声高回声进一步确定了猪肝内空化效应的存在。测定了不同乙醇浓度和体积对猪肝损伤体积和温度的影响。结果:HIFU联合乙醇注射使猪肝病变体积增大,病灶温度升高。在相同的HIFU照射功率下,乙醇体积的增加导致病灶体积和病灶温度的增加。在一定体积的乙醇注入和HIFU照射功率下,乙醇浓度越高,病变体积越大,病灶温度越高。结论:HIFU与乙醇联用对猪肝病变有协同影响,表现为乙醇浓度和体积越大,病变体积越大,病灶温度越高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Biomedical Physics and Engineering
Journal of Biomedical Physics and Engineering Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
2.90
自引率
0.00%
发文量
64
审稿时长
10 weeks
期刊介绍: The Journal of Biomedical Physics and Engineering (JBPE) is a bimonthly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research (experimental or theoretical) broadly concerned with the relationship of physics to medicine and engineering.
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