Neha Saini , Amit Kumar Tiwari , Robert Leahy , Nanasaheb Thorat , Atul Kulkarni
{"title":"Transforming brain cancer biomarker research with patinformatics and SWOT analysis","authors":"Neha Saini , Amit Kumar Tiwari , Robert Leahy , Nanasaheb Thorat , Atul Kulkarni","doi":"10.1016/j.drudis.2025.104314","DOIUrl":null,"url":null,"abstract":"<div><div>Brain cancer heterogeneity imposes significant challenges in diagnosis, causing high mortality. The lack of timely diagnosis intensifies these challenges, underscoring the need for improved diagnostics. Recent advancements in biomarker discovery have led to biomarker detection at ultra-low concentrations via multiplexing with biosensors, offering a promising avenue for the timely detection of brain cancer. Serving as a comprehensive resource, this review highlights the crucial role of primary biomarkers in brain cancer diagnosis via integration of patinformatics and SWOT analysis, thereby facilitating timely diagnosis and informed decision making. Furthermore, we aim to outline recent advances in brain cancer prognostics and management strategies, ultimately improving patient outcomes.</div></div>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":"30 3","pages":"Article 104314"},"PeriodicalIF":6.5000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1359644625000273","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Brain cancer heterogeneity imposes significant challenges in diagnosis, causing high mortality. The lack of timely diagnosis intensifies these challenges, underscoring the need for improved diagnostics. Recent advancements in biomarker discovery have led to biomarker detection at ultra-low concentrations via multiplexing with biosensors, offering a promising avenue for the timely detection of brain cancer. Serving as a comprehensive resource, this review highlights the crucial role of primary biomarkers in brain cancer diagnosis via integration of patinformatics and SWOT analysis, thereby facilitating timely diagnosis and informed decision making. Furthermore, we aim to outline recent advances in brain cancer prognostics and management strategies, ultimately improving patient outcomes.
期刊介绍:
Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed.
Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.