{"title":"Enhanced Bioactive Compound Absorption on PMMA Microwell Plates via Fine Controlling Air Plasma Treatment Time for Disease Diagnosis Applications.","authors":"Hailong Wang, Mengyao Wang, Jibo Tang, Yiman Zhang, Qingqian Wang, Yangming Hu, Wenjun Zhang, Xiaobo He, Hongxing Xu","doi":"10.1021/acs.langmuir.4c05082","DOIUrl":null,"url":null,"abstract":"<p><p>Microwell plates absorb bioactive compounds and are commonly used for disease prediction, diagnosis, and monitoring. Chemical absorption is more effective than physical absorption for stabilizing these compounds. This study systematically investigates the fundamental mechanisms of air plasma-induced surface modifications in poly(methyl methacrylate) (PMMA), focusing on carboxyl group formation kinetics, morphological evolution, and optical property changes. Air plasma treatment enhances the hydrophilicity and surface roughness of the PMMA plates. Light transmission remains comparable to untreated plates for 10 min treatment durations. Treatment for 3 min significantly increases the large-molecular-weight carboxyl compounds, with minimal loss after wash buffer rinsing. Thus, a 3 min air plasma treatment optimally enhances PMMA microwell plates for effective bioactive compound absorption.</p>","PeriodicalId":50,"journal":{"name":"Langmuir","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Langmuir","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.langmuir.4c05082","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Microwell plates absorb bioactive compounds and are commonly used for disease prediction, diagnosis, and monitoring. Chemical absorption is more effective than physical absorption for stabilizing these compounds. This study systematically investigates the fundamental mechanisms of air plasma-induced surface modifications in poly(methyl methacrylate) (PMMA), focusing on carboxyl group formation kinetics, morphological evolution, and optical property changes. Air plasma treatment enhances the hydrophilicity and surface roughness of the PMMA plates. Light transmission remains comparable to untreated plates for 10 min treatment durations. Treatment for 3 min significantly increases the large-molecular-weight carboxyl compounds, with minimal loss after wash buffer rinsing. Thus, a 3 min air plasma treatment optimally enhances PMMA microwell plates for effective bioactive compound absorption.
期刊介绍：
Langmuir is an interdisciplinary journal publishing articles in the following subject categories:
Colloids: surfactants and self-assembly, dispersions, emulsions, foams
Interfaces: adsorption, reactions, films, forces
Biological Interfaces: biocolloids, biomolecular and biomimetic materials
Materials: nano- and mesostructured materials, polymers, gels, liquid crystals
Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry
Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals
However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do?
Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*.
This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).
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