Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways.

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI:10.5114/aoms/184349

Kezban Kartlasmis, Ayse Nur Cakir Gungor, Yurdun Kuyucu, Samet Kara

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Abstract

The use of chemotherapeutic agents during childhood, adolescence, and early adulthood has a detrimental effect on ovarian functions, leading to a decrease in ovarian reserves, thus adversely affecting fertility. Alkylating agents are one of the most frequently used groups of chemotherapeutics in this age group. An important and effective chemotherapeutic drug, procarbazine is used to treat brain tumors and Hodgkin lymphoma in children, adolescents, and young adults. This agent is also an indispensable component of combination-type chemotherapy. Procarbazine has a detrimental impact on ovarian reserve by directly targeting the oocyte or indirectly through somatic cell destruction. Evidence gathered thus far indicates that procarbazine's mode of action in the ovaries may involve apoptosis, inflammation, and oxidative stress. This review seeks to clarify the processes by which procarbazine might induce apoptosis, inflammation, and oxidative stress, hence affecting ovarian reserve and functioning.

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丙卡嗪在凋亡、炎症和氧化途径中对卵巢储备破坏作用的评价综述。

在儿童、青少年和成年早期使用化疗药物对卵巢功能有不利影响，导致卵巢储备减少，从而对生育产生不利影响。烷基化剂是这一年龄组最常用的化疗药物之一。丙卡嗪是一种重要而有效的化疗药物，用于治疗儿童、青少年和年轻人的脑肿瘤和霍奇金淋巴瘤。该药也是联合化疗不可缺少的组成部分。丙卡嗪通过直接靶向卵母细胞或间接破坏体细胞对卵巢储备产生不利影响。迄今为止收集的证据表明，丙卡嗪在卵巢中的作用模式可能涉及细胞凋亡、炎症和氧化应激。本综述旨在阐明丙卡嗪可能诱导细胞凋亡、炎症和氧化应激的过程，从而影响卵巢储备和功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.