Cover Feature: Quinizarin Gold(I) N-Heterocyclic Carbene Complexes with Synergistic Activity Against Anthracycline-Resistant Leukaemia Cells: Synthesis and Biological Activity Studies (Chem. Eur. J. 11/2025)

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-02-20 DOI:10.1002/chem.202581104

Axel Steinbrueck, Matthew L. Reback, Christoph Rumancev, Daniel Siegmund, Jan Garrevoet, Gerald Falkenberg, Axel Rosenhahn, Aram Prokop, Nils Metzler-Nolte

引用次数: 0

Abstract

The Cover Feature, created by Aditi Mulik from the Ruhr-Universität Bochum, illustrates a cellular tug-of-war between the design goals for cancer therapeutics of prioritizing selective targeting or increased cytotoxicity. In the associated Research Article (DOI: 10.1002/chem.202404147), N. Metzler-Nolte and co-workers explain how mitochondrial targeting allowed the less-cytotoxic compound to overcome resistance mechanisms and re-sensitized cancer cells to treatment.

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来自波鸿鲁尔大学的 Aditi Mulik 制作的封面特写展示了癌症疗法的设计目标--优先选择靶向或增加细胞毒性--之间的细胞拉锯战。在相关研究文章（DOI: 10.1002/chem.202404147）中，N. Metzler-Nolte 及其合作者解释了线粒体靶向如何使毒性较低的化合物克服耐药机制，并使癌细胞对治疗重新敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.