Synthesis and antimicrobial activity of alkyl[2-(5-chloro-2-hydroxyphenyl)hex-1-en-1-yl]diphenylphosphonium salts

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-02-20 DOI:10.1007/s11172-024-4480-7

D. A. Tatarinov, E. A. Mikulenkova, N. V. Terekhova, A. V. Nemtarev, A. P. Lyubina, A. D. Voloshina, A. S. Sapunova, A. B. Dobrynin, I. A. Litvinov, V. F. Mironov

引用次数: 0

Abstract

A series of alkyl[2-(5-chloro-2-hydroxyphenyl)hex-1-en-1-yl]diphenylphosphonium salts were synthesized based on the predicted lipophilicity (logP). The synthesized salts exhibited high antimicrobial activity against gram-positive bacterial and fungal strains and high activity against the antibiotic-resistant Staphylococcus aureus (MRSA) strains. The most active compounds showed low cytotoxicity against human erythrocytes and liver cells and exhibited high selectivity indices.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.