[Effect of colostrum oral immune therapy on the the clinical outcomes in very low birth weight infants: a Meta analysis].

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-02-15 DOI:10.7499/j.issn.1008-8830.2406104

Yan Lu, Li-Li Wang, Li Wang, Ke-Ran Zhu

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引用次数: 0

Abstract

Objectives: To evaluate the effect of colostrum oral immune therapy (COIT) on clinical outcomes in very low birth weight (VLBW) infants.

Methods: A computer-based search was conducted in databases including China National Knowledge Infrastructure, Wanfang Data, Weipu Database, Chinese Biomedical Literature Service System, PubMed, Embase, Web of Science, the Cochrane Library, and CINAHL for randomized controlled trials regarding the application of COIT in VLBW infants published from the establishment of the database to February 2024. Meta analysis was performed using RevMan 5.3 software.

Results: A total of 14 randomized controlled trials were included, involving 1 386 VLBW infants, with 690 in the COIT group and 696 in the control group. The results showed that COIT significantly reduced the incidence of clinical late-onset sepsis (LOS) (RR=0.75, 95%CI: 0.64-0.88, P<0.001), the incidence of blood culture-proven LOS (RR=0.72, 95%CI: 0.57-0.92, P=0.008), mortality rate (RR=0.70, 95%CI: 0.52-0.95, P=0.020), the incidence of necrotizing enterocolitis (RR=0.65, 95%CI: 0.46-0.92, P=0.020), and the incidence of feeding intolerance (RR=0.49, 95%CI: 0.29-0.80, P=0.004). It also shortened the time to achieve full enteral nutrition (MD=-2.13, 95%CI: -4.03 to -0.23, P=0.030).

Conclusions: COIT can reduce the incidence rates of LOS, necrotizing enterocolitis, and feeding intolerance, as well as the mortality rate, while also shortening the time to achieve full enteral nutrition in VLBW infants.

查看原文本刊更多论文

[初乳口服免疫治疗对极低出生体重儿临床结局的影响：Meta分析]。

目的：评价初乳口服免疫治疗（COIT）对极低出生体重儿（VLBW）临床结局的影响。方法：计算机检索中国国家知识基础设施、万方数据、卫普数据库、中国生物医学文献服务系统、PubMed、Embase、Web of Science、Cochrane Library、CINAHL等数据库，检索自数据库建立至2024年2月已发表的关于COIT在VLBW婴儿中的应用的随机对照试验。采用RevMan 5.3软件进行Meta分析。结果：共纳入14项随机对照试验，共纳入1386例VLBW婴儿，其中COIT组690例，对照组696例。结果显示，COIT可显著降低临床晚发性脓毒症（LOS）发生率（RR=0.75, 95%CI: 0.64-0.88， PRR=0.72, 95%CI: 0.57-0.92， P=0.008）、死亡率（RR=0.70, 95%CI: 0.52-0.95， P=0.020）、坏死性小肠结肠炎发生率（RR=0.65, 95%CI: 0.46-0.92， P=0.020）、喂养不耐受发生率（RR=0.49, 95%CI: 0.29-0.80， P=0.004）。同时缩短了患者获得充分肠内营养的时间（MD=-2.13, 95%CI: -4.03 ~ -0.23， P=0.030）。结论：COIT可降低VLBW婴儿LOS、坏死性小肠结肠炎、喂养不耐受的发生率和死亡率，同时缩短实现完全肠内营养的时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.