Opportunistic screening for bone mineral density deficits in pediatric patients from abdominal computed tomography scans obtained for other indications: a cross-sectional study.

IF 2.1 3区医学 Q2 PEDIATRICS

Pediatric Radiology Pub Date : 2025-02-18 DOI:10.1007/s00247-025-06195-5

Chuan Liu, Dandan Yang, Xijian Chen, Yi Liao, Gang Ning, Haibo Qu

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引用次数: 0

Abstract

Background: Quantitative computed tomography (QCT) has been widely applied for opportunistic screening for osteoporosis in adults, but it is rarely used in pediatric patients.

Objective: This study aimed to investigate the feasibility of QCT and the prevalence of bone mineral density (BMD) deficits at the spine in pediatric patients undergoing an abdominal computed tomography (CT) for other indications.

Materials and methods: Pediatric patients who underwent a clinical abdominal CT scan from October 2018 to November 2020 were recruited for this retrospective cross-sectional study. Lumbar trabecular BMD was evaluated by QCT. The relationships of treatment variables and other potential risk factors with low BMD were analyzed via the signed-rank test and logistic regression analysis.

Results: A total of 748 pediatric patients were included. The QCT scans revealed low lumbar BMD (Z-score ≤ -2) in 86 (11.5%) patients. A history of chemotherapy or radiation therapy (β = 3.925, P < 0.001), a history of chronic corticosteroid exposure (β = 4.852, P < 0.001), older age (10.0-17.9 years vs. 1.0-9.9 years; β = 2.306, P = 0.001), and short stature (height ≤ the 3rd percentile vs. height > the 3rd percentile; β = 1.920, P = 0.047) were significantly associated with low BMD in pediatric patients.

Conclusion: QCT could be applied for opportunistic screening for low BMD in pediatric patients. Patients with cancer or renal disease, or those with a history of chemotherapy, radiation therapy, or chronic corticosteroid exposure, have a greater incidence of low BMD and constitute high-risk populations for BMD loss.

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来源期刊

Pediatric Radiology 医学-核医学

CiteScore

4.40

自引率

17.40%

发文量

300

审稿时长

3-6 weeks

期刊介绍： Official Journal of the European Society of Pediatric Radiology, the Society for Pediatric Radiology and the Asian and Oceanic Society for Pediatric Radiology Pediatric Radiology informs its readers of new findings and progress in all areas of pediatric imaging and in related fields. This is achieved by a blend of original papers, complemented by reviews that set out the present state of knowledge in a particular area of the specialty or summarize specific topics in which discussion has led to clear conclusions. Advances in technology, methodology, apparatus and auxiliary equipment are presented, and modifications of standard techniques are described. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.