The role of serum vaspin level in the early diagnosis of mesenteric ischemia induced in experimental animal model.

IF 1.9 3区 医学 Q2 EMERGENCY MEDICINE
Ömer Çelik, Uğur Doğan, Hamit Yaşar Ellidağ, Özlem Etli, Remzi Can Çakir, Turan Can Yildiz, Erhan Aydemir, Kemal Eyvaz
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引用次数: 0

Abstract

Purpose: Acute mesenteric ischaemia (AMI) is one of the abdominal surgical emergencies with high mortality and morbidity and early diagnosis and treatment are of vital importance. We aimed to evaluate the usefulness of serum vaspin level as a potential biomarker for early diagnosis of AMI in an experimental animal model.

Materials and methods: Sixty female Wistar-Albino rats were divided into 6 groups. Ischaemia groups (1, 3, 5) underwent SMA dissection and ligation, while control groups (2, 4, 6) did not. Blood and intestinal tissue samples were collected at 30 min, 2 h, and 6 h. Vaspin (ng/ml), TAS (Total antioxidant capacity, μmol Trolox equiv./L), TOS (Total oxidant capacity, μmol H2O2 equiv./L), ALT (Alanine Aminotransferase, U/L), AST (Aspartate Aminotransferase, U/L) and OSI (TOS/TAS) ratio of these biochemical values were studied.

Results: Vaspin levels were compared at 30 min, 2 h, and 6 h in ischaemia and control groups. No significant difference was found at 30 min and 2 h (p > 0.05), but a significant increase was observed at 6 h (p < 0.05). There was a statistically significant difference between the Vaspin (ng/ml) measurements of the ischaemia groups at three different times (p < 0.05). The highest Vaspin (ng/ml) value was obtained at the 6th hour and the lowest at the 30th minute.

Conclusion: In our study, a statistically significant increase in vaspin levels was detected with increasing ischaemia duration and necrosis. These findings suggest that vaspin may be a potential biomarker in the early diagnosis of AMI.

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来源期刊
CiteScore
4.50
自引率
14.30%
发文量
311
审稿时长
3 months
期刊介绍: The European Journal of Trauma and Emergency Surgery aims to open an interdisciplinary forum that allows for the scientific exchange between basic and clinical science related to pathophysiology, diagnostics and treatment of traumatized patients. The journal covers all aspects of clinical management, operative treatment and related research of traumatic injuries. Clinical and experimental papers on issues relevant for the improvement of trauma care are published. Reviews, original articles, short communications and letters allow the appropriate presentation of major and minor topics.
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