A novel hierarchical porous sheets of bimetallic terephthalate frameworks for the efficient detection of theophylline drug

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications Pub Date : 2025-02-16 DOI:10.1016/j.inoche.2025.114135

Monisha Venkatesan, Ganesan Shanmugam, Jeevanantham Arumugam, Sachin Sreedhar, Chandru Gunasekaran

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Abstract

A novel Cerium – Magnesium terephthalate frameworks (Ce-Mg TPFs) was synthesized by facile hydrothermal method and characterized by microscopic and spectroscopic techniques. Subsequently, Ce-Mg TPFs was casted on the glassy carbon electrode (Ce-Mg TPFs/GCE) for the amperometric sensing of the theophylline (TPH), a drug for treating various respiratory diseases. The electrochemical experiments were performed with Britton-Robinson (B-R) buffer solutions (pH 4.0) for irreversible electro-oxidation of TPH. The modified sensor shows greater stability, selectivity, reproducibility with low limit of detection (LOD) and limit of quantification (LOQ) of 0.07 µmol L⁻¹ and 0.25 µmol L⁻¹, respectively with the linear range of 1.0 × 10⁻^⁶ to 1.50 × 10⁻⁴ mol L⁻¹ and sensor mechanism was found to be diffusion-controlled phenomena. The proposed sensor offers a promising approach to monitor TPH levels in real-time (synthetic urine samples, TPH tablets and syrup solutions), allowing healthcare providers to adjust dosages and prevent toxicity.

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来源期刊

Inorganic Chemistry Communications 化学-无机化学与核化学

CiteScore

5.50

自引率

7.90%

发文量

1013

审稿时长

53 days

期刊介绍： Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.