Promise of rheumatoid arthritis therapy: From clinical deep remission to drug-free remission

IF 4.5 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2025-03-01 DOI:10.1016/j.berh.2024.102031

Yuke Hou , Yuanhong Peng , Jiayang Jin , Zhanguo Li

引用次数: 0

Abstract

Achieving clinical deep remission (CliDR) in rheumatoid arthritis (RA) is essential to prevent long-term joint damage, enhance patient quality of life, and possibly reduce and discontinue medication eventually. Recent research advances have raised the possibility of achieving deep remission and even drug-free remission. This comprehensive review examines current strategies of RA therapy, concept of deep remission, challenges, and the emerging prospects of drug-free remission. It also reviews the role of different treatments, including conventional disease-modifying antirheumatic drugs (DMARDs), biologic agents, and targeted synthetic drugs, in the journey from deep remission to drug-free remission. In addition, it emphasizes the importance of patient-centered care, early diagnosis, and individualized treatment approaches in optimizing outcomes for patients with RA.

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类风湿关节炎治疗的前景：从临床深度缓解到无药。

类风湿关节炎（RA）的临床深度缓解（CliDR）对于预防长期关节损伤，提高患者生活质量，最终可能减少和停药至关重要。最近的研究进展提高了实现深度缓解甚至无药物缓解的可能性。本文综述了目前RA治疗的策略、深度缓解的概念、挑战和无药缓解的新前景。它还回顾了不同治疗方法的作用，包括传统的疾病改善抗风湿药物（DMARDs）、生物制剂和靶向合成药物，在从深度缓解到无药物缓解的过程中。此外，它强调了以患者为中心的护理，早期诊断和个性化治疗方法在优化RA患者预后方面的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.