Clinical significance of Ki-67 in patients with lung adenocarcinoma in situ complicated by type 2 diabetes.

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2025-02-15 DOI:10.4239/wjd.v16.i2.98423

Ke Chen, Ge Wang, Jing-Cheng Hu, Ying-Yi Zhou, Hai-Tao Ma

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Abstract

Background: The increasing number of type 2 diabetes mellitus (T2DM) patients leads to higher rates of morbidity and mortality related to lung cancer.

Aim: To investigate the utility of the proliferating cell nuclear antigen Ki-67 in patients with lung adenocarcinoma in situ (AIS) complicated by T2DM.

Methods: One hundred patients with AIS and T2DM (group A), 100 patients with AIS alone (group B), and 60 patients with benign lung lesions (group C) admitted to the Department of Thoracic Surgery and Endocrinology of the First Affiliated Hospital of Soochow University from November 2021 to December 2022 were enrolled. Ki-67 expression was compared among the groups.

Results: Group A had significantly higher levels of fasting plasma glucose (FPG), total cholesterol (TC), total triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin (HbA1c), and insulin than groups B and C (P < 0.01). Meanwhile, group B had higher insulin levels than group C (P < 0.01). Group A exhibited a significantly higher average Ki-67 positivity rate than group B (P < 0.01). The Ki-67 positivity rate in group A was 86.87%, while the positivity rate in group B was 77%. Ki-67 was positively correlated with FPG (P < 0.01) and HbA1c levels (P < 0.01). Ki-67, FBG, insulin, HbA1c, high-density lipoprotein cholesterol and TC were independent factors for patients with AIS complicated by T2DM.

Conclusion: Ki-67 expression was higher in patients with AIS complicated by T2DM than in patients with AIS alone. Therefore, detecting the Ki-67 level might assist in the diagnosis of AIS in patients with T2DM.

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Ki-67在原位肺腺癌合并2型糖尿病患者中的临床意义。

背景：2型糖尿病（T2DM）患者数量的增加导致与肺癌相关的发病率和死亡率升高。目的：探讨增殖细胞核抗原Ki-67在肺原位腺癌（AIS）合并T2DM患者中的应用价值。方法：选取2021年11月至2022年12月苏州大学第一附属医院胸外科与内分泌科收治的AIS合并T2DM患者100例（A组）、单纯AIS患者100例（B组）、肺部良性病变患者60例（C组）。比较各组间Ki-67表达情况。结果：A组空腹血糖（FPG）、总胆固醇（TC）、总甘油三酯、低密度脂蛋白胆固醇、糖化血红蛋白（HbA1c）、胰岛素水平均显著高于B、C组（P < 0.01）。B组胰岛素水平高于C组（P < 0.01）。A组Ki-67平均阳性率显著高于B组（P < 0.01）。A组Ki-67阳性率为86.87%，B组阳性率为77%。Ki-67与FPG、HbA1c呈正相关（P < 0.01）。Ki-67、FBG、胰岛素、HbA1c、高密度脂蛋白胆固醇、TC是AIS合并T2DM患者的独立影响因素。结论：Ki-67在AIS合并T2DM患者中的表达高于单纯AIS患者。因此，检测Ki-67水平可能有助于T2DM患者AIS的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.