mRNA delivery with templated dynamic covalent polymers†

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-02-07 DOI:10.1039/D4CC06518B

José García Coll, Lamiaa M. A. Ali, Javier Montenegro, Nadir Bettache and Sébastien Ulrich

引用次数: 0

Abstract

Messenger RNA is a novel therapeutic modality which was key in curbing the Covid-19 pandemic. However, the delivery of mRNA in cells requires the development of smart vectors. We here report on amphiphilic dynamic covalent polymers formed in situ through RNA templating, and show effective nanoparticle formation and delivery of EGFP mRNA in cells.

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使用模板化动态共价聚合物输送 mRNA。

信使RNA是一种新的治疗方式，在遏制Covid-19大流行中发挥了关键作用。然而，mRNA在细胞中的传递需要智能载体的发展。我们在此报道了通过RNA模板原位形成的两亲性动态共价聚合物，并显示了EGFP mRNA在细胞中有效的纳米颗粒形成和传递。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.