Synthesis, Characterization, and Biological Activity of 5-Chloroquinolin-8-ol Complexes

Q3 Materials Science

Macromolecular Symposia Pub Date : 2025-02-17 DOI:10.1002/masy.202400224

Sakar Mubarak Abdalrazaq, Iyad Suleiman Hamad, Afraa Saber Shihab

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引用次数: 0

Abstract

This study involves the preparation of various organic compounds. Ethyl2-((5-chloroquinolin-8-yl)oxy)acetate compound (S1) is synthesized by the addition of potassium carbonate to 5-chloroquinolin-8-ol and ethylchloroacetate. 2-((5-chloroquinolin-8-yl)oxy)acetohydrazide (S2) are prepared by the reaction compound S1with hydrazine. Several complexes of Mannich bases are obtained by the reaction equimolar amounts of compound (S2) with the metal salt solution of cobalt and cadmium (MCl_n.XH₂O) (S3-S5), using ethanol as the solvent. The synthesized compounds and complexes are characterized using various spectroscopic techniques, including Fourier-Transform Infrared (FT-IR) spectroscopy, and nuclear magnetic resonance (¹H, ¹³C-NMR) spectroscopy. Additionally, their melting points, purity, molar conductivity, and magnetic susceptibility are determined. The impact of some prepared compounds and complexes on the growth of two antibiotic-resistant bacterial strains, namely the gram-negative Staphylococcus and the ram-positive Escherichia coli, is studied. Amoxicillin, is used as control antibiotic. Some of the synthesized compounds exhibited significant inhibitory activity against the tested bacterial strains.

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5-氯喹啉-8-醇配合物的合成、表征及生物活性研究

这项研究涉及到各种有机化合物的制备。用碳酸钾与5-氯喹啉-8-醇和氯乙酸乙酯加成，合成了2-（（5-氯喹啉-8-基）氧）乙酸乙酯化合物（S1）。2-（（5-氯喹啉-8-基）氧）乙酰肼（S2）由化合物s1与肼反应制备。以乙醇为溶剂，将等摩尔量的化合物（S2）与钴镉金属盐溶液（MCln.XH2O）（S3-S5）反应得到几种曼尼希碱配合物。合成的化合物和配合物使用各种光谱技术进行表征，包括傅里叶变换红外（FT-IR）光谱和核磁共振（1H, 13C-NMR）光谱。此外，还测定了它们的熔点、纯度、摩尔电导率和磁化率。研究了一些制备的化合物和复合物对革兰氏阴性葡萄球菌和革兰氏阳性大肠杆菌两种耐药菌株生长的影响。阿莫西林用作对照抗生素。部分合成的化合物对被试菌株表现出明显的抑制活性。

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来源期刊

Macromolecular Symposia Materials Science-Polymers and Plastics

CiteScore

1.50

自引率

0.00%

发文量

226

期刊介绍： Macromolecular Symposia presents state-of-the-art research articles in the field of macromolecular chemistry and physics. All submitted contributions are peer-reviewed to ensure a high quality of published manuscripts. Accepted articles will be typeset and published as a hardcover edition together with online publication at Wiley InterScience, thereby guaranteeing an immediate international dissemination.