Epidemiology of cancer in older adults: a systematic review of age-related differences in solid malignancies treatment.

IF 4.7 2区 医学 Q1 ONCOLOGY
Current Oncology Reports Pub Date : 2025-03-01 Epub Date: 2025-02-15 DOI:10.1007/s11912-025-01638-6
Esther Bastiaannet, Sophie Pilleron
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引用次数: 0

Abstract

Purpose of review: We examined the latest epidemiological research on age-related differences in cancer treatment and selected outcomes, among patients with cancer aged 60 and above in comparison to younger patients.

Recent findings: Colorectal, pancreatic and lung cancers were studied most often. Most studies were conducted in Europe or the United States of America (USA) within single centers. For unselected patients, older patients receive less treatment, and their survival, regardless of the metric used (cancer-specific survival or overall survival), was poorer than that of middle-aged patients. Age-related differences in treatment and outcomes were more pronounced in patients aged over 80 years. However, among patients selected for treatment, complications, adverse events rates and survival probabilities were comparable between older and younger patients. Treatment differences, especially the omission of therapy, were often smaller for good prognosis cancer types. The likelihood of receiving treatment decreased as age increases, regardless of the cancer types, treatment, countries and setting. More research on treatment in older patients with cancer, especially the frailest and the oldest, is urgently needed as there is still a lack of data to tailor treatment.

老年人癌症流行病学:对实体恶性肿瘤治疗中年龄相关差异的系统回顾。
综述目的:我们对60岁及以上癌症患者与年轻患者的年龄相关的癌症治疗差异和选择结果进行了最新的流行病学研究。最近的研究发现:结直肠癌、胰腺癌和肺癌是最常见的研究对象。大多数研究是在欧洲或美国的单中心进行的。对于未选择的患者,老年患者接受的治疗较少,无论使用的指标(癌症特异性生存或总生存),他们的生存都比中年患者差。年龄相关的治疗和结果差异在80岁以上的患者中更为明显。然而,在选择治疗的患者中,并发症、不良事件发生率和生存率在老年和年轻患者之间是相当的。对于预后良好的癌症类型,治疗差异,尤其是省略治疗,通常较小。无论癌症类型、治疗方法、国家和环境如何,接受治疗的可能性随着年龄的增长而下降。由于仍然缺乏量身定制治疗的数据,迫切需要对老年癌症患者的治疗进行更多的研究,特别是最虚弱和最年长的癌症患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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