Effect of Breathing a Krypton-Oxygen Mixture on Signaling Cascades in Rat Brain during Simulation of Photoinduced Ischemic Stroke.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-15 DOI:10.1007/s10517-025-06332-y

V V Antonova, I V Shumov, V T Dolgikh, A A Grebenchikova, M V Gabitov, E I Yakupova, O A Grebenchikov

引用次数: 0

Abstract

We studied the effect of a krypton-oxygen mixture on the key signaling pathways associated with ischemic tolerance and suppression of secondary damage in a model of photoinduced stroke in male Wistar rats. In animals breathing the krypton-oxygen mixture, the expression of the transcription factor NF-κB (p50) in the brain was suppressed, indicating anti-inflammatory shifts in the brain tissue upon exposure to krypton, in parallel, increased content of phosphorylated forms of glycogen synthase kinase 3β (GSK-3β) and protein kinase B (Akt), components of the preconditioning cascade, was revealed. These results indicate a high potential of krypton in reducing acute cerebral disorders.

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呼吸氪氧混合物对模拟光致缺血性脑卒中大鼠脑内信号级联的影响。

我们研究了氪氧混合物对雄性Wistar大鼠光致中风模型中与缺血耐受和抑制继发性损伤相关的关键信号通路的影响。在呼吸氪氧混合物的动物中，脑组织中转录因子NF-κB （p50）的表达被抑制，表明氪暴露后脑组织中的抗炎转移，同时，预处理级联成分糖原合成酶激酶3β (GSK-3β)和蛋白激酶B （Akt）磷酸化形式的含量增加。这些结果表明氪在减少急性脑疾病方面具有很高的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.