Shikha Sharma, B. V. Sunil Kumar, Kuldip Gupta, Ashwani Kumar
{"title":"Mammaglobin-A as a Diagnostic Marker of Canine Mammary Tumors: Insights from Immunohistochemical Analysis","authors":"Shikha Sharma, B. V. Sunil Kumar, Kuldip Gupta, Ashwani Kumar","doi":"10.1007/s40009-024-01444-x","DOIUrl":null,"url":null,"abstract":"<div><p>Mammaglobin-A (MAM-A) is a glycoprotein predominantly linked to mammary tissue. It is a secretory protein, characterized by its composition of 93 amino acids and a molecular weight of around 10 kDa. The primary objective of this study is to evaluate the tissue expression of MAM-A in different histotypes of canine mammary tumors (CMT). The present study includes a total of 40 samples of CMT and 5 samples of apparently healthy canine mammary tissues, which were subjected to histological and immunohistochemical examinations. Hyperimmune serum was generated against recombinant MAM-A (rMAM-A) in rabbits to establish a standardized immunohistochemical protocol for evaluating the expression of MAM-A protein in different histotypes of CMT. The histological study demonstrated a wide array of tumor classifications, predominantly consisting of carcinoma, followed by carcinosarcoma and sarcoma. The immunohistochemical examination demonstrated a pronounced expression of MAM-A in the majority of CMT histotypes. The immunohistochemical expression of MAM-A in CMT indicates its potential as a valuable diagnostic biomarker.</p></div>","PeriodicalId":717,"journal":{"name":"National Academy Science Letters","volume":"48 1","pages":"79 - 82"},"PeriodicalIF":1.2000,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"National Academy Science Letters","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1007/s40009-024-01444-x","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Mammaglobin-A (MAM-A) is a glycoprotein predominantly linked to mammary tissue. It is a secretory protein, characterized by its composition of 93 amino acids and a molecular weight of around 10 kDa. The primary objective of this study is to evaluate the tissue expression of MAM-A in different histotypes of canine mammary tumors (CMT). The present study includes a total of 40 samples of CMT and 5 samples of apparently healthy canine mammary tissues, which were subjected to histological and immunohistochemical examinations. Hyperimmune serum was generated against recombinant MAM-A (rMAM-A) in rabbits to establish a standardized immunohistochemical protocol for evaluating the expression of MAM-A protein in different histotypes of CMT. The histological study demonstrated a wide array of tumor classifications, predominantly consisting of carcinoma, followed by carcinosarcoma and sarcoma. The immunohistochemical examination demonstrated a pronounced expression of MAM-A in the majority of CMT histotypes. The immunohistochemical expression of MAM-A in CMT indicates its potential as a valuable diagnostic biomarker.
期刊介绍：
The National Academy Science Letters is published by the National Academy of Sciences, India, since 1978. The publication of this unique journal was started with a view to give quick and wide publicity to the innovations in all fields of science
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