Structure of T5-Like Phage dUTPase from Vibrio Phage Phi3

IF 0.6 4区 材料科学 Q4 CRYSTALLOGRAPHY
A. S. Glukhov, U. F. Dzhus, I. A. Kolyadenko, G. K. Selikhanov, A. G. Gabdulkhakov
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引用次数: 0

Abstract

The first crystal structure of dUTPase from the bacteriophage Vibrio phage phi3 was determined at 1.95 Å resolution. This protein has a homotrimeric quaternary structure characteristic of this type of dUTPases and contains a short loop in the N-terminal region of the polypeptide chain, which is specific for Т5-like bacteriophage dUTPases. It was demonstrated that, despite a low amino acid sequence homology between phage (Т5 and phi3) dUTPases, phi3 dUTPase can effectively replace phage Т5 dUTPase during the lytic cycle.

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来源期刊
Crystallography Reports
Crystallography Reports 化学-晶体学
CiteScore
1.10
自引率
28.60%
发文量
96
审稿时长
4-8 weeks
期刊介绍: Crystallography Reports is a journal that publishes original articles short communications, and reviews on various aspects of crystallography: diffraction and scattering of X-rays, electrons, and neutrons, determination of crystal structure of inorganic and organic substances, including proteins and other biological substances; UV-VIS and IR spectroscopy; growth, imperfect structure and physical properties of crystals; thin films, liquid crystals, nanomaterials, partially disordered systems, and the methods of studies.
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