Natural Products in Leukaemia Research: A Bibliometric Review

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2025-01-31 DOI:10.1016/j.hermed.2025.100993

Siddig Ibrahim Abdelwahab , Manal Mohamed Elhassan Taha , Syam Mohan

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引用次数: 0

Abstract

Introduction

This study evaluated the available literature concerning the diverse aspects of natural product activity against leukaemia.

Methods

Bibliometric data were obtained from the Scopus bibliographic database through search phrases developed from the MeSH database. Statistical analysis of the data was performed via Bibliometerix and VOSviewer. The search query was constructed on the basis of MeSH terms (D010936, D064209, and D007938) for the major topics. The data were further examined via bibliometric software tools such as Bibliometerix and VOSviewer.

Results

This bibliometric assessment covered original scientific articles from 1961 to 2023 in 1 039 journals and 4 704 documents with positive trends, which suggested a polynomial regression fit of the data (R² = 0.9346). The most active researcher is T. Efferth (Germany). The most advanced, cited, and collaborative nation is the United States. The key themes identified include ‘apoptosis,’ ‘cancer,’ ‘cytotoxicity,’ ‘HL-60 cells,’ and ‘Bcl-2.’ Thematic evolution reveals a shift toward emerging areas such as ‘molecular docking’ and ‘network pharmacology.’

Conclusions

These findings provide critical insights into research trends and highlight the evolving focus within leukaemia-related natural product studies, offering directions for future advancements.

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白血病研究中的天然产物：文献计量学综述

本研究评估了有关天然产物抗白血病活性的各个方面的现有文献。方法文献计量学数据从Scopus书目数据库中通过MeSH数据库开发的检索词获得。通过Bibliometerix和VOSviewer对数据进行统计分析。基于主要主题的MeSH术语（D010936、D064209和D007938）构建搜索查询。通过Bibliometerix和VOSviewer等文献计量软件工具进一步检查数据。结果本文献计量学评价涵盖1961 ~ 2023年1 039种期刊的原创科学论文和4 704篇正趋势文献，数据符合多项式回归拟合（R² = 0.9346）。最活跃的研究者是T. Efferth（德国）。最先进、被引用最多、最合作的国家是美国。确定的关键主题包括“细胞凋亡”、“癌症”、“细胞毒性”、“HL-60细胞”和“Bcl-2”。主题进化揭示了向“分子对接”和“网络药理学”等新兴领域的转变。这些发现为研究趋势提供了重要的见解，并突出了白血病相关天然产物研究的发展重点，为未来的发展提供了方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.