Thyroid comorbidities do not seem to negatively impact multiple sclerosis course: A single centre cohort study

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2025-02-11 DOI:10.1016/j.msard.2025.106323

Saridas Furkan , Saridas Mercan Filiz , Koc Emine Rabia , Cander Soner , Turan Omer Faruk

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Abstract

Multiple Sclerosis (MS) is a T-cell-mediated autoimmune disease with distinct clinical and pathologic phenotypes. Thyroid disorders play an essential role in studies evaluating the coexistence of both autoimmune and non-autoimmune diseases in MS patients. This study aimed to elucidate the characteristics of RRMS patients with thyroid pathologies and to determine the impact of the coexistence of both diseases on clinical or radiologic outcomes. Demographic, clinical, laboratory, and radiological data of patients with thyroid pathology (RRMS and thyroid pathology) who were followed up in our center for at least 12 months were retrospectively evaluated from patient files. Thyroid pathology was present in 34 patients with RRMS, 29 females and five males. Hashimoto's disease was the most common pathology. There was no significant difference between the presence or absence of thyroid pathologies in patients with RRMS in terms of clinical, radiologic, and laboratory characteristics. Thyroid pathologies, especially Hashimoto's disease, are among the most common autoimmune disorders in MS. This condition does not adversely affect the course of MS. On the other hand, no significant difference is expected in the hormonal follow-up of patients with Hashimoto's disease accompanying MS. Correction of thyroid pathology and hormone replacement therapy may be necessary for the course of MS. Further studies evaluating prospective standardized replacement therapies are needed.

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.