Twenty years in metalloprotein bioinformatics: A short history of a long journey

IF 3.8 2区 化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Claudia Andreini
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Abstract

The study of the structure and function of metalloproteins is a central subject of inorganic biochemistry. Starting from the 2000s, computational methods have flanked experimental research by exploiting the ever-increasing computing power and the huge amount of data produced by omics technologies. In this article, we retrace the major advancements that brought bioinformatics from being of minor relevance to being an essential tool for today's inorganic biochemists, focusing on the contributions coming from the Magnetic Resonance Center (CERM) of Florence, where we have been developing for twenty years methods and resources to investigate metalloproteins with computational approaches.

Abstract Image

金属蛋白生物信息学的二十年:漫长旅程的短暂历史
金属蛋白的结构和功能的研究是无机生物化学的中心课题。从2000年代开始,计算方法通过利用不断增长的计算能力和组学技术产生的大量数据来辅助实验研究。在这篇文章中,我们回顾了生物信息学的主要进展,这些进展使生物信息学从次要的相关到成为当今无机生物化学家的重要工具,重点关注来自佛罗伦萨磁共振中心(CERM)的贡献,在那里我们已经开发了20年的方法和资源,用计算方法来研究金属蛋白。
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来源期刊
Journal of Inorganic Biochemistry
Journal of Inorganic Biochemistry 生物-生化与分子生物学
CiteScore
7.00
自引率
10.30%
发文量
336
审稿时长
41 days
期刊介绍: The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.
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