A new dimeric sesquiterpenoid from Ajania fruticulosa

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-16 DOI:10.1016/j.phytol.2025.02.001

Xiaoran Min , Junping Chen , Wenhao Mu , Jiayi Huang , Guozheng Huang , Jianguo Cao

引用次数: 0

Abstract

One new sesquiterpenoid (1) and eighteen known natural compounds (2–19) were obtained from the aerial parts of Ajania fruticulosa. Their structures were established by spectroscopic methods, and the absolute configurations were further determined by single-crystal X-ray diffraction analysis for compounds 1 and 3. Compound 1 is a guaianolide-type dimeric sesquiterpenoid which might be a product of [4 + 2] addition reaction between compound 3 and its 1,2-dehydro analogue. Compound 12 showed a potent xanthine oxidase (XOD) inhibitory activity (IC₅₀ value of 23.82 ± 0.35 μM) and acted as a mixed-type inhibitor of XOD. Compounds 12 and 13 showed low toxicity while significantly inhibiting LPS-induced NO production in RAW264.7 cells.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.