Co-expression of LPHN3 and NKX3.1 as a predictive biomarker for metastasis in breast cancer.

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI:10.47391/JPMA.11127

Ramsha Khan, Mohiuddin Alamgir, Nehad Khan, Mohammad Bilal Khan, Farah Fatima Abbas, Saba Kamil

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引用次数: 0

Abstract

Objectives: To assess latrophilin-3 (LPHN3) and Homeobox protein (NKX- 3.1) protein expression in breast cancer, and the association with metastasis.

Methods: The case-control study was conducted at the Dow University of Health Sciences, Karachi, and comprised breast carcinoma tissue sections diagnosed between July and November 2022. The tissues were divided into 2 equal groups, with group A having cases with metastasis and group B having controls without metastasis. expression of latrophilin-3 and NKX3.1 in tissue was assessed using immunohistochemistry in both the groups. Data was analysed using SPSS 21.

Results: Of the 80 women with mean age 50±1.20 years, 40(50%) were in each of the 2 groups. Overall, 31(38.8%) tissues were from the right-side breast, and 49(61.2%) were from the left-side breast. Latrophilin-3 was highly expressed in group A 35(87.5%) compared to group B 10(25%) (p<0.001). The expression of NKX3.1 was weak in 10(25%) group A cases and 4(10%) group B controls (p=0.070).

Conclusions: The expression of latrophilin-3 could play an important role in the prediction of metastasis in earlystage breast cancers. In contrast, NKX3.1 expression had no significant association with metastasis.

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来源期刊

Journal of the Pakistan Medical Association Medicine-General Medicine

CiteScore

1.10

自引率

11.10%

发文量

983

审稿时长

3-6 weeks

期刊介绍： Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.