S I Barth, S M DeMonaco, B J Conner, A R Wilkinson
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引用次数: 0
Abstract
Objectives: Thromboelastography (TEG) using the TEG 6s, a point-of-care viscoelastic assay, was prospectively evaluated in dogs with chronic enteropathy (CE). Additionally, the study determined whether disease activity, assessed using the Canine Chronic Enteropathy Clinical Activity Index (CCECAI), correlated with TEG 6s parameters.
Materials and methods: A CCECAI score and TEG using the TEG 6s (Haemonetics®) was performed on 19 dogs with CE. In a separate study, TEG using the TEG 6s was performed on 40 healthy adult dogs, which served as the control group. For statistical analysis, normally distributed data were analysed using the two-sample t-test. Non-Gaussian data were analysed using the Wilcoxon rank sum test. Correlations between TEG 6s parameters and the CCECAI scores were assessed using the Pearson test for data with Gaussian distribution and the Spearman test for data with non-Gaussian distribution.
Results: Dogs with CE had significantly shortened mean clot kinetics, prolonged mean reaction time (R) and increased alpha angle (angle), maximum amplitude (MA) and RapidTEG™ MA compared to healthy dogs. Dogs with CE had a significant median increase in Functional Fibrinogen MA compared to healthy dogs. The CCECAI moderately positively correlated with angle.
Clinical significance: With the exception of prolonged R, dogs with CE have several TEG 6s alterations suggestive of hypercoagulability.
期刊介绍：
Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery.
In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world.
The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher.
The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association
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