Anti-inflammatory and Hepatoprotective Iridoid Glycosides from the Roots of Gomphandra mollis.

IF 3.6 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-02-13 DOI:10.1021/acs.jnatprod.4c01484

Quoc-Dung Tran Huynh, Thuy-Tien Thi Phan, Ta-Wei Liu, Thanh-Vu Nguyen, Truc-Ly Thi Duong, Su-Jung Hsu, Man-Hsiu Chu, Yun-Han Wang, Bien-Thuy Nguyen Bui, Dang-Khoa Nguyen, Thanh-Hoa Vo, Ching-Kuo Lee

{"title":"Anti-inflammatory and Hepatoprotective Iridoid Glycosides from the Roots of Gomphandra mollis.","authors":"Quoc-Dung Tran Huynh, Thuy-Tien Thi Phan, Ta-Wei Liu, Thanh-Vu Nguyen, Truc-Ly Thi Duong, Su-Jung Hsu, Man-Hsiu Chu, Yun-Han Wang, Bien-Thuy Nguyen Bui, Dang-Khoa Nguyen, Thanh-Hoa Vo, Ching-Kuo Lee","doi":"10.1021/acs.jnatprod.4c01484","DOIUrl":null,"url":null,"abstract":"Ten previously undescribed iridoid glycosides (1-10), including monoiridoids, hybrid iridoid-alkaloids, bis-iridoids, noriridoid-iridoid dimers, and tetramers, were isolated from the roots of Gomphandra mollis Merr. Structural elucidation revealed unique sugar chains not previously observed for iridoids and complex tetrameric configurations that are rare in nature. Compounds 9, 10, and 15 demonstrated significant anti-inflammatory effects, with IC50 values ranging from 6.13 to 13.0 μM, and compounds 6, 7, and 11-13 showed notable hepatoprotective activity in HepG2 cells. Additionally, structure-activity relationship (SAR) analysis on anti-inflammatory effects was also conducted. This study enriches the structural database of iridoids, particularly complex derivatives, and highlights their therapeutic potential in addressing inflammation-related and liver diseases.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"577-592"},"PeriodicalIF":3.6000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877508/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1021/acs.jnatprod.4c01484","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/13 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Ten previously undescribed iridoid glycosides (1-10), including monoiridoids, hybrid iridoid-alkaloids, bis-iridoids, noriridoid-iridoid dimers, and tetramers, were isolated from the roots of Gomphandra mollis Merr. Structural elucidation revealed unique sugar chains not previously observed for iridoids and complex tetrameric configurations that are rare in nature. Compounds 9, 10, and 15 demonstrated significant anti-inflammatory effects, with IC₅₀ values ranging from 6.13 to 13.0 μM, and compounds 6, 7, and 11-13 showed notable hepatoprotective activity in HepG2 cells. Additionally, structure-activity relationship (SAR) analysis on anti-inflammatory effects was also conducted. This study enriches the structural database of iridoids, particularly complex derivatives, and highlights their therapeutic potential in addressing inflammation-related and liver diseases.

查看原文本刊更多论文

Gomphandra mollis根中环烯醚萜苷的抗炎和保肝作用。

从Gomphandra mollis Merr的根中分离出10种先前未被描述过的环烯醚萜苷（1-10），包括单环烯醚萜、杂交环烯醚萜生物碱、双环烯醚萜、去甲环烯醚萜-环烯醚萜二聚体和四聚体。结构解析揭示了环烯醚萜类化合物和自然界罕见的复杂四聚体构型的独特糖链。化合物9、10和15具有显著的抗炎作用，IC50值在6.13 ~ 13.0 μM之间；化合物6、7和11-13对HepG2细胞具有显著的保肝活性。并对其抗炎作用进行构效关系（SAR）分析。本研究丰富了环烯醚萜的结构数据库，特别是复杂的衍生物，并强调了它们在治疗炎症相关疾病和肝脏疾病方面的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.