Anti-inflammatory and Hepatoprotective Iridoid Glycosides from the Roots of Gomphandra mollis.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-02-13 DOI:10.1021/acs.jnatprod.4c01484

Quoc-Dung Tran Huynh, Thuy-Tien Thi Phan, Ta-Wei Liu, Thanh-Vu Nguyen, Truc-Ly Thi Duong, Su-Jung Hsu, Man-Hsiu Chu, Yun-Han Wang, Bien-Thuy Nguyen Bui, Dang-Khoa Nguyen, Thanh-Hoa Vo, Ching-Kuo Lee

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引用次数: 0

Abstract

Ten previously undescribed iridoid glycosides (1-10), including monoiridoids, hybrid iridoid-alkaloids, bis-iridoids, noriridoid-iridoid dimers, and tetramers, were isolated from the roots of Gomphandra mollis Merr. Structural elucidation revealed unique sugar chains not previously observed for iridoids and complex tetrameric configurations that are rare in nature. Compounds 9, 10, and 15 demonstrated significant anti-inflammatory effects, with IC₅₀ values ranging from 6.13 to 13.0 μM, and compounds 6, 7, and 11-13 showed notable hepatoprotective activity in HepG2 cells. Additionally, structure-activity relationship (SAR) analysis on anti-inflammatory effects was also conducted. This study enriches the structural database of iridoids, particularly complex derivatives, and highlights their therapeutic potential in addressing inflammation-related and liver diseases.

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.