A tannic acid coated silk fibroin sponge loaded with bioglass for noncompressible hemostasis.

Abstract

A hemostatic sponge designed for hemostasis of noncompressible penetrating wounds should exhibit rapid shape recovery, strong coagulation activity, and effective antibacterial property. In this study, we prepared a tannic acid coated silk fibroin sponge loaded with bioglass. In vitro, the sponge had a three-dimensional porous structure, good liquid adsorption capacity, and a water-triggered shape recovery feature. The sponge possessed strong coagulation activity and antibacterial property, while exhibiting low cytotoxicity and minimal hemolytic effects. In vivo, the sponge showed a greater advantage in controlling bleeding from both rat liver injury and penetrating wounds compared to commercial gauze and gelatin sponge. In conclusion, the developed sponge can be promising for noncompressible hemostasis.