High-precision detection of chiral molecules based on optical weak value amplification in the ultraviolet band

IF 2 3区物理与天体物理 Q3 OPTICS

Applied Physics B Pub Date : 2025-02-13 DOI:10.1007/s00340-025-08386-2

Tingting Tang, Jingduo Xu, Yu He, Ying Gao, Xiao Liang, Jie Li, Chaoyang Li, Hao Tang, Hao Gu, Hangkong Bai

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Abstract

The detection of chiral molecules is highly important for drug safety; however, the chiral signals of chiral drugs are weak and are concentrated mainly in the ultraviolet band, and it is difficult for traditional methods to achieve precise detection. In this work, we apply a high-precision detection method for chiral molecules based on optical weak value amplification (WVA) in the ultraviolet band. By integrating WVA with ultraviolet spectrum analysis, we obtain the distribution of the intensity contrast ratio in the ultraviolet band, revealing the spectrum of the chiral signals. We demonstrate the application of this approach by detecting the optical rotatory dispersion (ORD) and circular dichroism (CD) of artemisinin with a high precision of 10^–6 rad, surpassing traditional detection methods. This work contributes to the precise detection of chiral spectra in the ultraviolet band and the recognition of chiral drugs, which is important in the pharmaceutical field.

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来源期刊

Applied Physics B 物理-光学

CiteScore

4.00

自引率

4.80%

发文量

202

审稿时长

3.0 months

期刊介绍： Features publication of experimental and theoretical investigations in applied physics Offers invited reviews in addition to regular papers Coverage includes laser physics, linear and nonlinear optics, ultrafast phenomena, photonic devices, optical and laser materials, quantum optics, laser spectroscopy of atoms, molecules and clusters, and more 94% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again Publishing essential research results in two of the most important areas of applied physics, both Applied Physics sections figure among the top most cited journals in this field. In addition to regular papers Applied Physics B: Lasers and Optics features invited reviews. Fields of topical interest are covered by feature issues. The journal also includes a rapid communication section for the speedy publication of important and particularly interesting results.